KWZY-11 is a PARP/CDK6 Dual Inhibitor. KWZY-11 effectively induces excessive DNA damage and apoptosis inMDA-MB-231 cells, while maintaining robust inhibitory activity against both PARP and CDK6. Additionally, KWZY-11 demonstrates excellent antitumor efficacy and antimetastatic properties, with no evident toxicity or side effects observed. Further investigations revealed that KWZY-11 could inhibit tumor cell proliferation by modulating the Wnt/β-catenin signaling pathway.
MedKoo Cat#: 129010
Name: KWZY-11
CAS#: N/A
Chemical Formula: C28H27ClN8O2
Exact Mass: 542.1945
Molecular Weight: 543.03
Elemental Analysis: C, 61.93; H, 5.01; Cl, 6.53; N, 20.64; O, 5.89
The following data is based on the product molecular weight 543.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
