Aditerin is a gene therapy treatment for high-risk non–muscle-invasive bladder cancer (NMIBC) that is unresponsive to Bacillus Calmette-Guérin (BCG) therapy. It utilizes a non-replicating adenoviral vector to deliver the gene encoding human interferon alpha 2B (IFNα2b) into bladder urothelial cells. Once inside the cells, the IFNα2b gene is expressed, leading to the production and secretion of IFNα2b, a cytokine that enhances the body's immune response against cancer cells .
MedKoo Cat#: 146394
Name: Aditerin
CAS#: 56066-19-4
Chemical Formula: C13H17N5O2
Exact Mass: 275.1382
Molecular Weight: 275.31
Elemental Analysis: C, 56.71; H, 6.22; N, 25.44; O, 11.62
The following data is based on the product molecular weight 275.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
