MedKoo Cat#: 128984 | Name: BY13

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BY13 is a potent SRC‑3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer. BY13 could significantly inhibit the growth of drug-resistant breast tumors without observed toxicity in mice. Mechanism studies indicated that the degradation ability of these SRC-3 PROTAC degraders is ubiquitin proteasome system (UPS) pathway-dependent. Moreover, BY13 displays a highly selective blocking effect on the ER signaling pathway over that of the androgen receptor. This proof-of-concept study firmly confirms that SRC-3 is a promising therapeutic target for breast cancer treatment and highlights BY13 as a lead compound for developing novel therapeutics to overcome endocrine resistance in breast cancer.

Chemical Structure

BY13
BY13
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128984

Name: BY13

CAS#: N/A

Chemical Formula: C35H41N9O4

Exact Mass: 651.3282

Molecular Weight: 651.77

Elemental Analysis: C, 64.50; H, 6.34; N, 19.34; O, 9.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BY13; BY 13; BY-13
IUPAC/Chemical Name
(E)-2-(2,6-dioxopiperidin-3-yl)-4-(4-(3-(2-(2-(1-(pyridin-2-yl)ethylidene)hydrazineyl)-1H-benzo[d]imidazol-1-yl)azetidin-1-yl)piperidin-1-yl)hexahydro-1H-isoindole-1,3(2H)-dione
InChi Key
BWIBSHUCQGYRAR-LALXJTNGSA-N
InChi Code
InChI=1S/C35H41N9O4/c1-21(25-8-4-5-16-36-25)39-40-35-37-26-9-2-3-10-27(26)43(35)23-19-42(20-23)22-14-17-41(18-15-22)28-11-6-7-24-31(28)34(48)44(33(24)47)29-12-13-30(45)38-32(29)46/h2-5,8-10,16,22-24,28-29,31H,6-7,11-15,17-20H2,1H3,(H,37,40)(H,38,45,46)/b39-21+
SMILES Code
C/C(C1=NC=CC=C1)=N\NC2=NC(C=CC=C3)=C3N2C4CN(C5CCN(C6CCCC(C(N7C8CCC(NC8=O)=O)=O)C6C7=O)CC5)C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 651.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liang J, Wang D, Wu Y, Shi J, Xie B, Xiao R, Ni J, Wang C, Dong C, Shu HB, Li S, Zhou HB. Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer. J Med Chem. 2025 May 28. doi: 10.1021/acs.jmedchem.5c00425. Epub ahead of print. PMID: 40434408.