Synonym
DSPE-PEG(2000)-Azide; 1,2-DSPE-PEG(2000)-azide 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-azide; azide-DSPE-PEG2000; DSPE-PEG2k-azide
IUPAC/Chemical Name
(2R)-3-(((2-(((2-(2-azidoethoxy)ethoxy)carbonyl)amino)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate
InChi Key
IWKYAYGGFRMWFO-VZUYHUTRSA-N
InChi Code
InChI=1S/C46H89N4O11P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44(51)58-41-43(42-60-62(54,55)59-38-35-48-46(53)57-40-39-56-37-36-49-50-47)61-45(52)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h43H,3-42H2,1-2H3,(H,48,53)(H,54,55)/t43-/m1/s1
SMILES Code
CCCCCCCCCCCCCCCCCC(OC[C@H](COP(O)(OCCNC(OCCOCCN=[N+]=[N-])=O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
905.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. D’Acunzo, F., Carbonaro, L., Cort, A.D., et al. Click‐connected 2‐(hydroxyimino)aldehydes for the design of UV‐responsive functional molecules. Eur. J. Org. Chem. 2, 289-294 (2021).
2. Xiao, Y., Liu, Q., Clulow, A.J., et al. PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery. Colloids Surf. B Biointerfaces 182, 110362 (2019).
3. Zaleski, M.H., Omo-Lamai, S., Nong, J., et al. Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy. J. Control. Release 374, 425-440 (2024).
4. Dyer, M.R., Hickman, D., Luc, N., et al. Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis. J. Trauma Acute Care Surg. 84(6), 917-923 (2018).
-Azide3807.jpg "DSPE-PEG(2000)-Azide")
