JAB-3312 is a potent, selective, and orally bioavailable small-molecule inhibitor of the protein tyrosine phosphatase SHP2 (Src homology region 2-containing protein tyrosine phosphatase 2), a key regulator of the RAS/MAPK signaling pathway. By inhibiting SHP2, JAB-3312 disrupts oncogenic signaling driven by receptor tyrosine kinases and RAS mutations. In biochemical assays, JAB-3312 demonstrates nanomolar potency against SHP2, and in cell-based assays, it inhibits downstream ERK phosphorylation, confirming effective pathway suppression. Preclinical studies have shown that JAB-3312 inhibits tumor growth in xenograft models of SHP2-dependent cancers, including EGFR-mutant and KRAS-mutant tumors, particularly when used in combination with other agents such as MEK or KRAS G12C inhibitors.
MedKoo Cat#: 556396
Name: JAB-3312
CAS#: 2245082-05-5
Chemical Formula: C21H22ClN7S
Exact Mass: 439.1346
Molecular Weight: 439.97
Elemental Analysis: C, 57.33; H, 5.04; Cl, 8.06; N, 22.29; S, 7.29
The following data is based on the product molecular weight 439.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
