IUPAC/Chemical Name
2-((2-isopropylphenoxy)methyl)-4,5-dihydro-1H-imidazole
InChi Key
GFYSWQDCHLWRMQ-UHFFFAOYSA-N
InChi Code
1S/C13H18N2O/c1-10(2)11-5-3-4-6-12(11)16-9-13-14-7-8-15-13/h3-6,10H,7-9H2,1-2H3,(H,14,15)
SMILES Code
CC(C)C1=CC=CC=C1OCC2=NCCN2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
218.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hauet T, Ramassamy A, Badia P, Julien N, Robert R, Touchard G, Patte D. Nécrose digitale associée à une intoxication par la fenoxazoline. A propos d'un cas et revue de la littérature [Digital necrosis associated with fenoxazoline poisoning. Apropos of a case and review of the literature]. Rev Med Interne. 1996;17(1):66-9. French. doi: 10.1016/0248-8663(96)88398-6. PMID: 8677387.
2: Bucaretchi F, Dragosavac S, Vieira RJ. Exposição aguda a derivados imidazolínicos em crianças [Acute exposure to imidazoline derivatives in children]. J Pediatr (Rio J). 2003 Nov-Dec;79(6):519-24. Portuguese. PMID: 14685449.
3: Lorino AM, Lofaso F, Dahan E, Coste A, Harf A, Lorino H. Combined effects of a mechanical nasal dilator and a topical decongestant on nasal airflow resistance. Chest. 1999 Jun;115(6):1514-8. doi: 10.1378/chest.115.6.1514. PMID: 10378542.
4: Humbert H, Cabiac MD, Dubray C, Lavène D. Human pharmacokinetics of dihydroergotamine administered by nasal spray. Clin Pharmacol Ther. 1996 Sep;60(3):265-75. doi: 10.1016/S0009-9236(96)90053-3. PMID: 8841149.
5: Levrier J, Molon-Noblot S, Duval D, Lloyd KG. A new ex vivo method for the study of nasal drops on ciliary function. Fundam Clin Pharmacol. 1989;3(5):471-82. doi: 10.1111/j.1472-8206.1989.tb00682.x. PMID: 2481638.
6: Oliveira CA, Braga CR, Solé D, Naspitz CK. Azelastina intranasal no tratamento da rinite alérgica perene em crianças [Intranasal azelastine in the treatment of perennial allergic rhinitis in children]. J Pediatr (Rio J). 1996 Nov-Dec;72(6):394-9. Portuguese. doi: 10.2223/jped.650. PMID: 14688906.
7: Kim L, Baek S, Son K, Kim E, Noh HH, Kim D, Oh MS, Moon BC, Ro JH. Optimization of a Simplified and Effective Analytical Method of Pesticide Residues in Mealworms (Tenebrio molitor Larvae) Combined with GC-MS/MS and LC-MS/MS. Molecules. 2020 Jul 31;25(15):3518. doi: 10.3390/molecules25153518. PMID: 32752108; PMCID: PMC7435900.
8: Dimitriou R, De Gaudemaris R, Blanc-Jouvan F, Perdrix A, Mallion JM. Hypertension artérielle par abus des vasoconstricteurs nasaux. A propos d'une observation [Arterial hypertension caused by abuse of nasal constrictors. Apropos of a case]. Rev Med Interne. 1984 Sep;5(3):231-2. French. doi: 10.1016/s0248-8663(84)80060-0. PMID: 6209761.
9: Balansard P, Mathieu F, Normand P, Frances Y, Luccioni R. Hypertension artérielle créée par un décongestionnant nasal. Intérêt de l'utilisation d'un mode d'enregistrement automatique et programmable [Arterial hypertension induced by a nasal decongestant. Value of the use of an automatic and programmable recording technic]. Sem Hop. 1983 Dec 1;59(44):3059-61. French. PMID: 6198723.
