Angiopep-2-cys | A conjugate of Angiopep-2 HCl and cysteine | CAS#906480-09-9

MedKoo Cat#: 128968 | Name: Angiopep-2-Cys

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine.

Chemical Structure

Angiopep-2-Cys

CAS#906480-09-9

Theoretical Analysis

MedKoo Cat#: 128968

Name: Angiopep-2-Cys

CAS#: 906480-09-9

Chemical Formula: C107H154N30O32S

Exact Mass: 2403.1066

Molecular Weight: 2404.65

Elemental Analysis: C, 53.45; H, 6.46; N, 17.47; O, 21.29; S, 1.33

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 650.00	2 Weeks

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Related CAS #

No Data

Synonym

Angiopep-2-Cys; Angiopep2-Cys; Angiopep-2Cys

IUPAC/Chemical Name

(2R,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,41S,50S,53S,56S,59S,60R)-59-amino-23,26-bis(2-amino-2-oxoethyl)-17,32-bis(4-aminobutyl)-20,53,56-tribenzyl-8,11-bis(2-carboxyethyl)-29,38-bis(3-guanidinopropyl)-60-hydroxy-5,50-bis(4-hydroxybenzyl)-14-((R)-1-hydroxyethyl)-41-(hydroxymethyl)-2-(mercaptomethyl)-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58-nonadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaazahenhexacontanoic acid

InChi Key

NTEVJSCQHIRPSH-ZYRNEBAYSA-N

InChi Code

InChI=1S/C107H154N30O32S/c1-56(139)87(112)103(166)135-75(46-60-22-10-5-11-23-60)98(161)131-73(45-59-20-8-4-9-21-59)97(160)129-71(47-61-28-32-63(141)33-29-61)90(153)120-51-82(145)119-52-83(146)123-78(54-138)102(165)124-65(26-16-42-117-106(113)114)89(152)121-53-84(147)122-66(24-12-14-40-108)91(154)125-68(27-17-43-118-107(115)116)92(155)133-76(49-80(110)143)101(164)134-77(50-81(111)144)100(163)132-72(44-58-18-6-3-7-19-58)96(159)126-67(25-13-15-41-109)95(158)137-88(57(2)140)104(167)128-70(37-39-86(150)151)93(156)127-69(36-38-85(148)149)94(157)130-74(48-62-30-34-64(142)35-31-62)99(162)136-79(55-170)105(168)169/h3-11,18-23,28-35,56-57,65-79,87-88,138-142,170H,12-17,24-27,36-55,108-109,112H2,1-2H3,(H2,110,143)(H2,111,144)(H,119,145)(H,120,153)(H,121,152)(H,122,147)(H,123,146)(H,124,165)(H,125,154)(H,126,159)(H,127,156)(H,128,167)(H,129,160)(H,130,157)(H,131,161)(H,132,163)(H,133,155)(H,134,164)(H,135,166)(H,136,162)(H,137,158)(H,148,149)(H,150,151)(H,168,169)(H4,113,114,117)(H4,115,116,118)/t56-,57-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,87+,88+/m1/s1

SMILES Code

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,404.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Kafa H, Wang JT, Rubio N, Klippstein R, Costa PM, Hassan HA, Sosabowski JK, Bansal SS, Preston JE, Abbott NJ, Al-Jamal KT. Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo. J Control Release. 2016 Mar 10;225:217-29. doi: 10.1016/j.jconrel.2016.01.031. Epub 2016 Jan 23. PMID: 26809004; PMCID: PMC4778610.