MedKoo Cat#: 128964 | Name: SKLB-D18
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5.

Chemical Structure

SKLB-D18
SKLB-D18
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128964

Name: SKLB-D18

CAS#: N/A

Chemical Formula: C22H25ClN6O2S

Exact Mass: 472.1448

Molecular Weight: 472.99

Elemental Analysis: C, 55.87; H, 5.33; Cl, 7.49; N, 17.77; O, 6.77; S, 6.78

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 1,750.00 2 Weeks
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Related CAS #
No Data
Synonym
SKLB-D18; SKLBD18; SKLB D18
IUPAC/Chemical Name
4-(5-chloro-2-((3-((dimethylamino)methyl)phenyl)amino)pyrimidin-4-yl)-N-morpholinothiophene-2-carboxamide
InChi Key
JXVORTVTLKOYIT-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25ClN6O2S/c1-28(2)13-15-4-3-5-17(10-15)25-22-24-12-18(23)20(26-22)16-11-19(32-14-16)21(30)27-29-6-8-31-9-7-29/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,27,30)(H,24,25,26)
SMILES Code
CN(C)CC1=CC=CC(NC2=NC(C3=CSC(C(NN4CCOCC4)=O)=C3)=C(Cl)C=N2)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 472.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Xiao H, Wang A, Shuai W, Qian Y, Wu C, Wang X, Yang P, Sun Q, Wang G, Ouyang L, Sun Q. A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy. Signal Transduct Target Ther. 2025 Feb 20;10(1):70. doi: 10.1038/s41392-025-02169-z. PMID: 39979271; PMCID: PMC11842588.