MedKoo Cat#: 128962 | Name: GPX4-IN-6
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPX4-IN-6 is a covalent inhibitor of glutathione peroxidase 4 (GPX4; IC50 = 130 nM).

Chemical Structure

GPX4-IN-6
GPX4-IN-6
CAS#2922824-07-3

Theoretical Analysis

MedKoo Cat#: 128962

Name: GPX4-IN-6

CAS#: 2922824-07-3

Chemical Formula: C18H17BrFNO5

Exact Mass: 425.0274

Molecular Weight: 426.24

Elemental Analysis: C, 50.72; H, 4.02; Br, 18.75; F, 4.46; N, 3.29; O, 18.77

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
GPX4-IN-6; Glutathione Peroxidase 4-IN-6; Glutathione Peroxidase 4 Inhibitor 6; GPX4 Inhibitor 6
IUPAC/Chemical Name
2-bromo-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)acetamide
InChi Key
RKMUVAANQXYLLV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17BrFNO5/c1-23-15-8-12(9-16(24-2)18(15)20)21(17(22)10-19)11-3-4-13-14(7-11)26-6-5-25-13/h3-4,7-9H,5-6,10H2,1-2H3
SMILES Code
O=C(CBr)N(C1=CC(OC)=C(C(OC)=C1)F)C2=CC=C3OCCOC3=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 426.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chen, T., Leng, J., Tan, J., et al. Discovery of novel potent covalent glutathione peroxidase 4 inhibitors as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer. J. Med. Chem. 66(14), 10036-10059 (2023).