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MedKoo Cat#: 146378 | Name: Thiotaurine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiotaurine is a synthetic amino acid derivative of taurine, known for its antioxidant and cytoprotective properties. It helps neutralize reactive oxygen species (ROS) and protects cells from oxidative stress, particularly in the skin. Thiotaurine is commonly used in cosmetic and skincare formulations to combat environmental damage and support healthy skin function. Its mechanism involves scavenging free radicals and supporting cellular defense systems.

Chemical Structure

Thiotaurine
Thiotaurine
CAS#2937-54-4

Theoretical Analysis

MedKoo Cat#: 146378

Name: Thiotaurine

CAS#: 2937-54-4

Chemical Formula: C2H7NO2S2

Exact Mass: 140.9918

Molecular Weight: 141.20

Elemental Analysis: C, 17.01; H, 5.00; N, 9.92; O, 22.66; S, 45.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Thiotaurine;
IUPAC/Chemical Name
2-aminoethane-1-sulfonothioic S-acid
InChi Key
SHWIJIJNPFXOFS-UHFFFAOYSA-N
InChi Code
1S/C2H7NO2S2/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)
SMILES Code
NCCS(S)(=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 141.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baseggio Conrado A, Capuozzo E, Mosca L, Francioso A, Fontana M. Thiotaurine: From Chemical and Biological Properties to Role in H2S Signaling. Adv Exp Med Biol. 2019;1155:755-771. doi: 10.1007/978-981-13-8023-5_66. PMID: 31468446. 2: Karpowicz SJ, Anderson L. Enzymatic and non-enzymatic conversion of cystamine to thiotaurine and taurine. Biochim Biophys Acta Gen Subj. 2022 Dec;1866(12):130225. doi: 10.1016/j.bbagen.2022.130225. Epub 2022 Aug 18. PMID: 35988704; PMCID: PMC9637780. 3: Wang D, Xie A, Luo J, Li L, Zhang Z, Deng W, Yang B, Chang Y, Liang Y. Thiotaurine inhibits melanoma progression by enhancing Ca2+ overload- induced cellular apoptosis. J Dermatol Sci. 2025 Apr;118(1):29-37. doi: 10.1016/j.jdermsci.2025.03.001. Epub 2025 Mar 15. PMID: 40189970. 4: Capuozzo E, Baseggio Conrado A, Fontana M. Thiotaurine modulates human neutrophil activation. Adv Exp Med Biol. 2015;803:145-55. doi: 10.1007/978-3-319-15126-7_13. PMID: 25833495. 5: Kuroda M, Nagasaki T, Koito T, Hongo Y, Yoshida T, Maruyama T, Tsuchida S, Nemoto S, Inoue K. Possible Roles of Hypotaurine and Thiotaurine in the Vesicomyid Clam Phreagena okutanii. Biol Bull. 2021 Feb;240(1):34-40. doi: 10.1086/712396. Epub 2021 Feb 9. PMID: 33730534. 6: Capuozzo E, Pecci L, Baseggio Conrado A, Fontana M. Thiotaurine prevents apoptosis of human neutrophils: a putative role in inflammation. Adv Exp Med Biol. 2013;775:227-36. doi: 10.1007/978-1-4614-6130-2_19. PMID: 23392938. 7: Dragotto J, Capuozzo E, Fontana M, Curci A, Fiorenza MT, Canterini S. Thiotaurine protects mouse cerebellar granule neurons from potassium deprivation-induced apoptosis by inhibiting the activation of caspase-3. Adv Exp Med Biol. 2015;803:513-23. doi: 10.1007/978-3-319-15126-7_41. PMID: 25833523. 8: Capuozzo E, Giorgi A, Canterini S, Baseggio Conrado A, Giarrusso P, Schininà ME, Fontana M. A Proteomic Approach to Study the Effect of Thiotaurine on Human Neutrophil Activation. Adv Exp Med Biol. 2017;975 Pt 1:563-571. doi: 10.1007/978-94-024-1079-2_44. PMID: 28849482. 9: Yancey PH, Ishikawa J, Meyer B, Girguis PR, Lee RW. Thiotaurine and hypotaurine contents in hydrothermal-vent polychaetes without thiotrophic endosymbionts: correlation With sulfide exposure. J Exp Zool A Ecol Genet Physiol. 2009 Jul 1;311(6):439-47. doi: 10.1002/jez.541. PMID: 19402134. 10: Pruski AM, Fiala-Médioni A. Stimulatory effect of sulphide on thiotaurine synthesis in three hydrothermal-vent species from the East Pacific Rise. J Exp Biol. 2003 Sep;206(Pt 17):2923-30. doi: 10.1242/jeb.00513. PMID: 12878661. 11: Pandya KG, Budhram R, Clark G, Lau-Cam CA. Comparative evaluation of taurine and thiotaurine as protectants against diabetes-induced nephropathy in a rat model. Adv Exp Med Biol. 2013;775:371-94. doi: 10.1007/978-1-4614-6130-2_29. PMID: 23392948. 12: Budhram R, Pandya KG, Lau-Cam CA. Protection by taurine and thiotaurine against biochemical and cellular alterations induced by diabetes in a rat model. Adv Exp Med Biol. 2013;775:321-43. doi: 10.1007/978-1-4614-6130-2_27. PMID: 23392946. 13: Iciek M, Bilska-Wilkosz A, Górny M. Sulfane sulfur - new findings on an old topic. Acta Biochim Pol. 2019 Dec 28;66(4):533-544. doi: 10.18388/abp.2019_2909. PMID: 31883321. 14: Rosenberg NK, Lee RW, Yancey PH. High contents of hypotaurine and thiotaurine in hydrothermal-vent gastropods without thiotrophic endosymbionts. J Exp Zool A Comp Exp Biol. 2006 Aug 1;305(8):655-62. doi: 10.1002/jez.a.316. PMID: 16788898. 15: Mathew E, Barletta MA, Lau-Cam CA. The effects of taurine and thiotaurine on oxidative stress in the aorta and heart of diabetic rats. Adv Exp Med Biol. 2013;775:345-69. doi: 10.1007/978-1-4614-6130-2_28. PMID: 23392947. 16: Chou PH, Hu MY, Guh YJ, Wu GC, Yang SH, Tandon K, Shao YT, Lin LY, Chen C, Tseng KY, Wang MC, Zhang CM, Han BC, Lin CC, Tang SL, Jeng MS, Chang CF, Tseng YC. Cellular mechanisms underlying extraordinary sulfide tolerance in a crustacean holobiont from hydrothermal vents. Proc Biol Sci. 2023 Jan 11;290(1990):20221973. doi: 10.1098/rspb.2022.1973. Epub 2023 Jan 11. PMID: 36629118; PMCID: PMC9832567. 17: Inoue K, Tsukuda K, Koito T, Miyazaki Y, Hosoi M, Kado R, Miyazaki N, Toyohara H. Possible role of a taurine transporter in the deep-sea mussel Bathymodiolus septemdierum in adaptation to hydrothermal vents. FEBS Lett. 2008 Apr 30;582(10):1542-6. doi: 10.1016/j.febslet.2008.03.052. Epub 2008 Apr 7. PMID: 18396164. 18: CAVALLINI D, MONDOVI B, GIOVANELLA B, DE MARCO C. Degradation of thiotaurine by ionizing radiations. Nature. 1959 Sep 5;184:61. PMID: 13848179. 19: Yancey PH, Blake WR, Conley J. Unusual organic osmolytes in deep-sea animals: adaptations to hydrostatic pressure and other perturbants. Comp Biochem Physiol A Mol Integr Physiol. 2002 Nov;133(3):667-76. doi: 10.1016/s1095-6433(02)00182-4. PMID: 12443924. 20: Acharya M, Lau-Cam CA. Comparative evaluation of the effects of taurine and thiotaurine on alterations of the cellular redox status and activities of antioxidant and glutathione-related enzymes by acetaminophen in the rat. Adv Exp Med Biol. 2013;776:199-215. doi: 10.1007/978-1-4614-6093-0_20. PMID: 23392884.