BTT-3034 is a sulfonamide-based inhibitor of the α2β1 integrin, exhibiting an EC₅₀ of 160 nM for inhibiting CHO-α2β1 cell adhesion to collagen I, with a maximal inhibition (Eₘₐₓ) of 86% . While it demonstrates selectivity for α2β1 over α1β1 integrins, its selectivity is approximately 2-fold, which is lower compared to BTT-3033's 8-fold selectivity . Notably, BTT-3034 does not inhibit platelet adhesion to collagen I under flow conditions, indicating a lack of efficacy in dynamic shear stress environments . In vivo, BTT-3034 has shown moderate anti-inflammatory effects; in a mouse model of arachidonic acid-induced ear edema
MedKoo Cat#: 556394
Name: BTT-3034
CAS#: 1259029-47-4
Chemical Formula: C22H21N5O3S
Exact Mass: 467.1086
Molecular Weight: 467.56
Elemental Analysis: C, 56.51; H, 4.53; N, 14.98; O, 10.27; S, 13.71
The following data is based on the product molecular weight 467.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
