Synonym
Pentigetide; Pentyde;
IUPAC/Chemical Name
L-aspartyl-L-seryl-L-aspartyl-L-prolyl-L-arginine
InChi Key
KQDIGHIVUUADBZ-PEDHHIEDSA-N
InChi Code
1S/C22H36N8O11/c23-10(7-15(32)33)17(36)29-13(9-31)18(37)28-12(8-16(34)35)20(39)30-6-2-4-14(30)19(38)27-11(21(40)41)3-1-5-26-22(24)25/h10-14,31H,1-9,23H2,(H,27,38)(H,28,37)(H,29,36)(H,32,33)(H,34,35)(H,40,41)(H4,24,25,26)/t10-,11-,12-,13-,14-/m0/s1
SMILES Code
N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
588.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mansmann HC Jr, Rosen J, Ziering R, Hampel F, Ratner P, Findlay S, Kniker W, Haddad Z, Daigle A. Pentigetide nasal solution: a multicenter study evaluating efficacy and safety in patients with seasonal allergic rhinitis. Ann Allergy. 1991 Oct;67(4):409-15. PMID: 1952297.
2: Kalpaxis JG, Thayer TO. Double-blind trial of pentigetide ophthalmic solution, 0.5%, compared with cromolyn sodium, 4%, ophthalmic solution for allergic conjunctivitis. Ann Allergy. 1991 May;66(5):393-8. PMID: 1903616.
3: Hamburger RN. Pentapeptide activity. Ann Allergy. 1992 Jan;68(1):68. PMID: 1736721.
4: Casillas Miranda R, Boudet RV, Vanella LM. Alternativas de la inmunoterapia clásica y posibilidades futuras [Alternatives to classical immunotherapy and future possibilities]. Rev Alerg Mex (1987). 1990 Jul-Aug;37(4):133-5. Spanish. PMID: 2089604.
5: Coutts SM, Reid DM. Purification of small peptides labeled with Bolton-Hunter reagent. Anal Biochem. 1978 Dec;91(2):446-50. doi: 10.1016/0003-2697(78)90530-4. PMID: 9762130.
6: Bennetts JS, Fowles LF, Berkman JL, van Bueren KL, Richman JM, Simpson F, Wicking C. Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Gene. 2006 Jun 7;374:153-65. doi: 10.1016/j.gene.2006.01.027. Epub 2006 Mar 20. PMID: 16546331.
7: MURAKAMI T. The coloring matters of Xanthoria fallax (Hepp.) Arn. fallacinal and fallacinol. Pharm Bull. 1956 Aug;4(4):298-302. doi: 10.1248/cpb1953.4.298. PMID: 13378955.
8: MESCHIA G. A rigid membrane for measurement of colloidal osmotic pressure with the Hepp osmometer. Yale J Biol Med. 1954 Dec;27(3):206-12. PMID: 13226958; PMCID: PMC2599420.
9: Cohen GA, O'Connor RD, Hamburger RN. Safety and efficacy of human IgE pentapeptide. Ann Allergy. 1984 Feb;52(2):83-6. PMID: 6364896.
10: Prenner BM. Double-blind placebo-controlled trial of intranasal IgE pentapeptide. Ann Allergy. 1987 May;58(5):332-5. PMID: 3578925.
11: DESPLAS B. A propos de la communication de M.J. Hepp sur les anastomoses bilio-digestives [On J. Hepp's article on bilio-digestive anastomoses]. Mem Acad Chir (Paris). 1951 May 23-30;77(18-19):587-8. Undetermined Language. PMID: 14863046.
12: Casillas Miranda R, Boudet RV, Vanella LM. Alternativas de la inmunoterapia clásica y posibilidades futuras [Alternatives to classic immunotherapy and future possibilities]. Rev Alerg Mex (1987). 1990 May-Jun;37(3):101-4. Spanish. PMID: 2087619.
13: RADERMECKER MA, VAN BOGAERT L. Deux observations de polymyosite aiguë généralisée (Wagner-Hepp) [Two case reports on acute disseminated Wagner-Hepp polymyositis]. Rev Neurol (Paris). 1955;92(3):182-94. French. PMID: 13255494.
