Tangeretin | CAS#481-53-8 | flavone

MedKoo Cat#: 146353 | Name: Tangeretin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tangeretin is a polymethoxylated flavone found predominantly in the peel of citrus fruits such as tangerines and oranges. It is known for its anti-inflammatory, antioxidant, and anticancer properties. Tangeretin works by modulating key cellular signaling pathways, including inhibition of NF-κB and activation of apoptosis in cancer cells, as well as enhancing cellular resistance to oxidative stress.

Chemical Structure

Tangeretin

CAS#481-53-8

Theoretical Analysis

MedKoo Cat#: 146353

Name: Tangeretin

CAS#: 481-53-8

Chemical Formula: C20H20O7

Exact Mass: 372.1209

Molecular Weight: 372.37

Elemental Analysis: C, 64.51; H, 5.41; O, 30.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Tangeretin;

IUPAC/Chemical Name

5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

InChi Key

ULSUXBXHSYSGDT-UHFFFAOYSA-N

InChi Code

1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3

SMILES Code

COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(OC)=C(OC)C(OC)=C3OC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 372.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liang M, Ye H, Shen Q, Jiang X, Cui G, Gu W, Zhang LH, Naqvi NI, Deng YZ. Tangeretin inhibits fungal ferroptosis to suppress rice blast. J Integr Plant Biol. 2021 Dec;63(12):2136-2149. doi: 10.1111/jipb.13175. Epub 2021 Nov 2. PMID: 34570416. 2: Raza W, Luqman S, Meena A. Prospects of tangeretin as a modulator of cancer targets/pathways. Pharmacol Res. 2020 Nov;161:105202. doi: 10.1016/j.phrs.2020.105202. Epub 2020 Sep 15. PMID: 32942013. 3: Ashrafizadeh M, Ahmadi Z, Mohammadinejad R, Ghasemipour Afshar E. Tangeretin: a mechanistic review of its pharmacological and therapeutic effects. J Basic Clin Physiol Pharmacol. 2020 Apr 23;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0191/jbcpp-2019-0191.xml. doi: 10.1515/jbcpp-2019-0191. PMID: 32329752. 4: Liu Y, Zhang Y, You G, Zheng D, He Z, Guo W, Antonina K, Shukhrat Z, Ding B, Zan J, Zhang Z. Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis. Inflamm Res. 2024 Jan;73(1):47-63. doi: 10.1007/s00011-023-01819-8. Epub 2023 Dec 26. PMID: 38147126. 5: Shi Y, Chen J, Li S, Wu Y, Yu C, Ni L, Xiao J, Shao Z, Zhu H, Wang J, Wang X, Zhang X. Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways. Phytomedicine. 2022 Apr;98:153928. doi: 10.1016/j.phymed.2022.153928. Epub 2022 Jan 5. PMID: 35104760. 6: de Luna FCF, Ferreira WAS, Casseb SMM, de Oliveira EHC. Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin. Pharmaceuticals (Basel). 2023 Aug 30;16(9):1229. doi: 10.3390/ph16091229. PMID: 37765037; PMCID: PMC10537037. 7: Xu Y, Yan X, Zhuang J, Hao H. The Anticancer Perspective of Tangeretin: A Small Review. Molecules. 2025 Jan 13;30(2):300. doi: 10.3390/molecules30020300. PMID: 39860170; PMCID: PMC11767889. 8: Peng B, Hu J, Sun Y, Huang Y, Peng Q, Zhao W, Xu W, Zhu L. Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway. Phytother Res. 2024 Sep;38(9):4555-4569. doi: 10.1002/ptr.8294. Epub 2024 Jul 25. PMID: 39054118. 9: Anto EM, Jayamurthy P. Tangeretin enhances pancreatic beta-TC-6 function by ameliorating tunicamycin-induced cellular perturbations. Mol Biol Rep. 2023 Dec 29;51(1):43. doi: 10.1007/s11033-023-09013-z. PMID: 38158492. 10: Bai Y, Xiong Y, Zhang YY, Cheng L, Liu H, Xu K, Wu YY, Field J, Wang XD, Zhou LM. Tangeretin Synergizes with 5-Fluorouracil to Induce Autophagy through MicroRNA-21 in Colorectal Cancer Cells. Am J Chin Med. 2022;50(6):1681-1701. doi: 10.1142/S0192415X22500719. Epub 2022 Jul 15. PMID: 35848125. 11: Wu C, Zhao J, Chen Y, Li T, Zhu R, Zhu B, Zhang Y. Tangeretin protects human brain microvascular endothelial cells against oxygen-glucose deprivation-induced injury. J Cell Biochem. 2019 Apr;120(4):4883-4891. doi: 10.1002/jcb.27762. Epub 2018 Sep 27. PMID: 30260010. 12: Arafa EA, Shurrab NT, Buabeid MA. Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways. Adv Pharmacol Pharm Sci. 2021 Mar 5;2021:4709818. doi: 10.1155/2021/4709818. PMID: 33748757; PMCID: PMC7954633. 13: Chiangsaen P, Maneesai P, Kukongviriyapan U, Tong-Un T, Ishida W, Prachaney P, Pakdeechote P. Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension. Reprod Toxicol. 2020 Sep;96:1-10. doi: 10.1016/j.reprotox.2020.05.012. Epub 2020 May 30. PMID: 32479886. 14: Wani I, Koppula S, Balda A, Thekkekkara D, Jamadagni A, Walse P, Manjula SN, Kopalli SR. An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders. Life (Basel). 2024 Apr 14;14(4):504. doi: 10.3390/life14040504. PMID: 38672774; PMCID: PMC11051149. 15: Sun Y, Liu L, Qiu C. Tangeretin protects mice from diet-induced metabolic inflammation via activating adipose lactate accumulation and macrophage M2 polarization. Biochem Biophys Res Commun. 2022 Nov 19;630:16-23. doi: 10.1016/j.bbrc.2022.09.044. Epub 2022 Sep 14. PMID: 36126465. 16: Brack ME, Boterberg T, Depypere HT, Stove C, Leclercq G, Mareel MM. The citrus methoxyflavone tangeretin affects human cell-cell interactions. Adv Exp Med Biol. 2002;505:135-9. doi: 10.1007/978-1-4757-5235-9_12. PMID: 12083457. 17: Guo J, Chen Y, Yuan F, Peng L, Qiu C. Tangeretin Protects Mice from Alcohol- Induced Fatty Liver by Activating Mitophagy through the AMPK-ULK1 Pathway. J Agric Food Chem. 2022 Sep 14;70(36):11236-11244. doi: 10.1021/acs.jafc.2c02927. Epub 2022 Sep 5. PMID: 36063077. 18: Wang W, Jia T, Zhang Y, Zhou Y. Progress of Researches on Pharmacological Effects and Bioavailability of Tangeretin. J Oleo Sci. 2025;74(1):13-23. doi: 10.5650/jos.ess24169. PMID: 39756989. 19: Gv V, Ranganathan P Jr, Palati S. Tangeretin's Anti-apoptotic Signaling Mechanisms in Oral Cancer Cells: In Vitro Anti-cancer Activity. Cureus. 2023 Oct 22;15(10):e47452. doi: 10.7759/cureus.47452. PMID: 38022093; PMCID: PMC10660419. 20: Liu Y, Han J, Zhou Z, Li D. Tangeretin inhibits streptozotocin-induced cell apoptosis via regulating NF-κB pathway in INS-1 cells. J Cell Biochem. 2019 Mar;120(3):3286-3293. doi: 10.1002/jcb.27596. Epub 2018 Sep 14. PMID: 30216514.