MedKoo Cat#: 146352 | Name: Ligustrazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ligustrazine, also known as tetramethylpyrazine (TMP), is a bioactive compound extracted from the traditional Chinese medicinal herb Ligusticum chuanxiong. It is primarily used for its neuroprotective and cardiovascular benefits, including improving blood circulation, reducing platelet aggregation, and protecting against ischemic injury. Ligustrazine exerts its effects through antioxidant activity, calcium channel modulation, and inhibition of inflammatory pathways.

Chemical Structure

Ligustrazine
Ligustrazine
CAS#1124-11-4

Theoretical Analysis

MedKoo Cat#: 146352

Name: Ligustrazine

CAS#: 1124-11-4

Chemical Formula: C8H12N2

Exact Mass: 136.1000

Molecular Weight: 136.20

Elemental Analysis: C, 70.55; H, 8.88; N, 20.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ligustrazine; Chuanxingzine;
IUPAC/Chemical Name
2,3,5,6-tetramethylpyrazine
InChi Key
FINHMKGKINIASC-UHFFFAOYSA-N
InChi Code
1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
SMILES Code
CC1=NC(C)=C(C)N=C1C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 136.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mu Q, Yao K, Syeda MZ, Zhang M, Cheng Q, Zhang Y, Sun R, Lu Y, Zhang H, Luo Z, Huang H, Liu X, Luo C, Zhu X, Wu S, Cui L, Huang C, Chen X, Tang L. Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia-Reperfusion Injury. Adv Sci (Weinh). 2023 Jul;10(19):e2301348. doi: 10.1002/advs.202301348. Epub 2023 Apr 20. PMID: 37078794; PMCID: PMC10323616. 2: Jiang X, Li S, Wang N, Li J. Ligustrazine as a multitarget scaffold in drug design and discovery. Bioorg Med Chem. 2025 Apr 15;121:118110. doi: 10.1016/j.bmc.2025.118110. Epub 2025 Feb 11. PMID: 39955802. 3: Gao HJ, Liu PF, Li PW, Huang ZY, Yu FB, Lei T, Chen Y, Cheng Y, Mu QC, Huang HY. Ligustrazine monomer against cerebral ischemia/reperfusion injury. Neural Regen Res. 2015 May;10(5):832-40. doi: 10.4103/1673-5374.156991. PMID: 26109963; PMCID: PMC4468780. 4: Chen X, Yang T, Zhou Y, Mei Z, Zhang W. Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury. CNS Neurosci Ther. 2024 Apr;30(4):e14725. doi: 10.1111/cns.14725. PMID: 38615367; PMCID: PMC11016344. 5: Zhang Q, Wang J, Zhu L, Jiang SJ, Liu J, Wang LX, Qin XH. Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats. Curr Med Sci. 2021 Jun;41(3):548-554. doi: 10.1007/s11596-021-2379-1. Epub 2021 Jun 25. PMID: 34169425. 6: Wen Y, Zhang Z, Cai Z, Liu B, Wu Z, Liu Y. Ligustrazine-Loaded Borneol Liposome Alleviates Cerebral Ischemia-Reperfusion Injury in Rats. ACS Biomater Sci Eng. 2022 Nov 14;8(11):4930-4941. doi: 10.1021/acsbiomaterials.2c00847. Epub 2022 Oct 13. PMID: 36227861. 7: Yang H, Xu G, Li Q, Zhu L. Ligustrazine alleviates the progression of coronary artery calcification by inhibiting caspase-3/GSDME mediated pyroptosis. Biosci Trends. 2024 Nov 15;18(5):482-491. doi: 10.5582/bst.2024.01096. Epub 2024 Jul 6. PMID: 38972749. 8: Ji R, Gan Q, Shu X, Xu R, Huang X, Shen T. The efficacy of Salvia- ligustrazine and Ligustrazine in treating gestational hypertension: A systematic review and meta-analysis. Biomol Biomed. 2024 Oct 17;24(6):1517-1534. doi: 10.17305/bb.2024.10743. PMID: 39115338; PMCID: PMC11496844. 9: Qiu JL, Zhang GF, Chai YN, Han XY, Zheng HT, Li XF, Duan F, Chen LY. Ligustrazine Attenuates Liver Fibrosis by Targeting miR-145 Mediated Transforming Growth Factor-β/Smad Signaling in an Animal Model of Biliary Atresia. J Pharmacol Exp Ther. 2022 Jun;381(3):257-265. doi: 10.1124/jpet.121.001020. Epub 2022 Apr 9. PMID: 35398813. 10: Yuan Y, Zhao L, Wang X, Lian F, Cai Y. Ligustrazine-induced microRNA-16-5p inhibition alleviates preeclampsia through IGF-2. Reproduction. 2020 Dec;160(6):905-917. doi: 10.1530/REP-20-0309. PMID: 33112793. 11: Chen Y, Xing Z, Chen J, Sun C, Liu Y, Peng C, Peng F, Li D. SIRT1 activation by Ligustrazine ameliorates migraine via the paracrine interaction of microglia and neurons. Phytomedicine. 2024 Dec;135:156069. doi: 10.1016/j.phymed.2024.156069. Epub 2024 Sep 17. PMID: 39341123. 12: Shao H, Zhao L, Chen F, Zeng S, Liu S, Li J. Efficacy of Ligustrazine Injection as Adjunctive Therapy for Angina Pectoris: A Systematic Review and Meta-Analysis. Med Sci Monit. 2015 Nov 29;21:3704-15. doi: 10.12659/msm.895362. PMID: 26615387; PMCID: PMC4671452. 13: Li H, Yang M. Ligustrazine activate the PPAR-γ pathway and play a protective role in vascular calcification. Vascular. 2022 Dec;30(6):1224-1231. doi: 10.1177/17085381211051477. Epub 2021 Oct 20. PMID: 34670463. 14: Feng Y, Dong H, Zheng L. Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis. Pharm Biol. 2023 Dec;61(1):666-673. doi: 10.1080/13880209.2023.2195883. PMID: 37095705; PMCID: PMC10132247. 15: Chen RJ, Chen MC, Tsai BC, Roy R, Chang YR, Wang TF, Kuo WW, Kuo CH, Yao CH, Li CC, Huang CY. Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats. Chem Biol Drug Des. 2023 Dec;102(6):1399-1408. doi: 10.1111/cbdd.14327. Epub 2023 Aug 23. PMID: 37612133. 16: Wang Y, Zhu H, Tong J, Li Z. Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma. Comput Math Methods Med. 2022 Jan 10;2022:1452116. doi: 10.1155/2022/1452116. PMID: 35047052; PMCID: PMC8763486. 17: Lian N, Tong J, Zhu W, Meng Q, Jiang M, Bian M, Li Y. Ligustrazine and liguzinediol protect against doxorubicin-induced cardiomyocytes injury by inhibiting mitochondrial apoptosis and autophagy. Clin Exp Pharmacol Physiol. 2023 Nov;50(11):867-877. doi: 10.1111/1440-1681.13811. Epub 2023 Aug 13. PMID: 37574718. 18: Jiang G, Xin R, Yuan W, Zhang L, Meng X, Sun W, Han H, Hou Y, Wang L, Du P. Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation. Int J Mol Med. 2020 Mar;45(3):731-742. doi: 10.3892/ijmm.2020.4464. Epub 2020 Jan 10. PMID: 31985025; PMCID: PMC7015130. 19: Li L, Chen H, Shen A, Li Q, Chen Y, Chu J, Liu L, Peng J, Chen K. Ligustrazine inhibits platelet activation via suppression of the Akt pathway. Int J Mol Med. 2019 Jan;43(1):575-582. doi: 10.3892/ijmm.2018.3970. Epub 2018 Nov 1. PMID: 30387814. 20: Zou J, Gao P, Hao X, Xu H, Zhan P, Liu X. Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives. Eur J Med Chem. 2018 Mar 10;147:150-162. doi: 10.1016/j.ejmech.2018.01.097. Epub 2018 Feb 5. PMID: 29432947.