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MedKoo Cat#: 146347 | Name: Butethal

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Butethal is a barbiturate derivative with sedative and hypnotic properties, primarily used in the past for short-term treatment of insomnia and as a pre-anesthetic agent. It acts by enhancing the activity of the inhibitory neurotransmitter GABA at GABA-A receptors, leading to central nervous system depression. This results in sedation, reduced anxiety, and sleep induction.

Chemical Structure

Butethal
Butethal
CAS#77-28-1

Theoretical Analysis

MedKoo Cat#: 146347

Name: Butethal

CAS#: 77-28-1

Chemical Formula: C10H16N2O3

Exact Mass: 212.1161

Molecular Weight: 212.25

Elemental Analysis: C, 56.59; H, 7.60; N, 13.20; O, 22.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Butethal; Butobarbital; Butobarbitone;
IUPAC/Chemical Name
5-butyl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione
InChi Key
STDBAQMTJLUMFW-UHFFFAOYSA-N
InChi Code
1S/C10H16N2O3/c1-3-5-6-10(4-2)7(13)11-9(15)12-8(10)14/h3-6H2,1-2H3,(H2,11,12,13,14,15)
SMILES Code
CCCCC1(CC)C(=O)NC(=O)NC1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 212.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: López-Muñoz F, Ucha-Udabe R, Alamo-González C. Un siglo de barbitúricos en neurologia [A century of barbiturates in neurology]. Rev Neurol. 2004 Oct 16-31;39(8):767-75. Spanish. PMID: 15514906. 2: Chou CH, Rowland M. Effect of altered tissue binding on the disposition of barbital in the isolated perfused rat liver: application of the axial dispersion model. J Pharm Sci. 1997 Nov;86(11):1310-4. doi: 10.1021/js960481d. PMID: 9383746. 3: Dixit BN, Abraham DJ. Barbiturates. Structural comparisons. I. Amobarbital, methylamobarbital, and butethal. J Med Chem. 1969 Mar;12(2):330-2. doi: 10.1021/jm00302a035. PMID: 5783613. 4: Chang BL, Nuessle NO, Haney WG Jr. Characterization of hydrogen bonding between selected barbiturates and polyethylene glycol 4000 by IR spectral analysis. J Pharm Sci. 1975 Nov;64(11):1787-97. doi: 10.1002/jps.2600641110. PMID: 1195109. 5: Ratsimbazafy V, Andrianabelina R, Randrianarisona S, Preux PM, Odermatt P. Treatment gap for people living with epilepsy in Madagascar. Trop Doct. 2011 Jan;41(1):38-9. doi: 10.1258/td.2010.100254. Epub 2010 Dec 1. PMID: 21123488. 6: Haider G, Kislinger T, Kutchan TM. Barbiturate induced benzophenanthridine alkaloid formation proceeds by gene transcript accumulation in the California poppy. Biochem Biophys Res Commun. 1997 Dec 18;241(2):606-10. doi: 10.1006/bbrc.1997.7842. PMID: 9425319. 7: López-Muñoz F, Ucha-Udabe R, Alamo C. The history of barbiturates a century after their clinical introduction. Neuropsychiatr Dis Treat. 2005 Dec;1(4):329-43. PMID: 18568113; PMCID: PMC2424120. 8: De Broe ME, Verpooten GA, Christiaens MA, Rutsaert RJ, Holvoet J, Nagler J, Heyndrickx A. Clinical experience with prolonged combined hemoperfusion- hemodialysis treatment of severe poisoning. Artif Organs. 1981 Feb;5(1):59-66. PMID: 7247757. 9: GOULDING R, HELLIWELL PJ, KERR AC, WILKIN EM. Sedation of children as out- patients for dental operations under general anaesthesia; trial of methylpentynol, butobarbitone, and chlorpromazine. Br Med J. 1957 Apr 13;1(5023):855-60. doi: 10.1136/bmj.1.5023.855. PMID: 13413235; PMCID: PMC1973613. 10: HINTON JM. The actions of amylobarbitone sodium, butobarbitone and quinalbarbitone sodium upon insomnia and nocturnal restlessness compared in psychiatric patients. Br J Pharmacol Chemother. 1961 Feb;16(1):82-9. doi: 10.1111/j.1476-5381.1961.tb00300.x. PMID: 13714480; PMCID: PMC1482001. 11: Maurer HH. Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry. J Chromatogr. 1990 Sep 14;530(2):307-26. doi: 10.1016/s0378-4347(00)82334-8. PMID: 2079506. 12: Timmermann G, Czeizel AE, Bánhidy F, Acs N. A study of the teratogenic and fetotoxic effects of large doses of barbital, hexobarbital and butobarbital used for suicide attempts by pregnant women. Toxicol Ind Health. 2008 Feb- Mar;24(1-2):109-19. doi: 10.1177/0748233708089004. PMID: 18818187. 13: Helliwell M. Severe barbiturate and paracetamol overdose: the simultaneous removal of both poisons by haemoperfusion. Postgrad Med J. 1980 May;56(655):363-5. doi: 10.1136/pgmj.56.655.363. PMID: 7443601; PMCID: PMC2425606. 14: Fischer E, Gregus Z, Varga F. Effects of barbiturates on the hepatic cytochrome P-450 dependent enzyme system and biliary excretion of exogenous organic anions in rats. Digestion. 1980;20(2):115-20. doi: 10.1159/000198428. PMID: 6767638. 15: Simon P, Hakkou F, Warot D. Influence de certains medicaments sur les differents procedes de contraception [Drug interactions with contraceptive methods]. Contracept Fertil Sex (Paris). 1984 Mar;12(3):479-82. French. PMID: 12265944. 16: Mohammadi R, Gaudoneix-Taieb M, Armand-Branger S, Beauverie P, Poisson N. Place de l'alimémazine parmi les hypnotiques dans un établissement de soins psychiatriques [Value of trimeprazine among hypnotics in a psychiatric facility]. Encephale. 2000 Sep-Oct;26(5):75-80. French. PMID: 11192808. 17: Draguet-Brughmans M, Draux P, Bouché R. Polymorphisme du butobarbital [Polymorphism of butobarbital (author's transl)]. J Pharm Belg. 1981 Nov- Dec;36(6):397-403. French. PMID: 7328481. 18: Fischer E, Gregus Z, Varga F. Hepatic microsomal induction and hepatic transport. Acta Med Acad Sci Hung. 1979;36(2):203-9. PMID: 94738. 19: Yong FC, Nadarajah K, Krishnamoorthy S. Crush syndrome following sedative- hypnotic overdosage. Singapore Med J. 1987 Dec;28(6):562-5. PMID: 2894717. 20: ANDREJEW A, DUCET G, LOUW J, ROSENBERG AJ. Influence de la chlorpromazine, du sonéryl et du penthiobarbital sur l'activité ATP-asique [Influence of chlorpromazine, soneryl and penthiobarbital on ATPase activity]. C R Seances Soc Biol Fil. 1956;150(3):509-11. French. PMID: 13343728.

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JTH-601 free base

JTH-601 free base