Nissol is a selective inverse agonist of the histamine H3 receptor (H3R), a G-protein coupled receptor predominantly expressed in the central nervous system. By binding to the H3R, Nissol stabilizes the receptor in its inactive state, reducing its constitutive activity and thereby enhancing the release of histamine and other neurotransmitters such as dopamine, acetylcholine, and norepinephrine. This modulation of neurotransmitter release can improve cognitive functions, attention, and wakefulness. Consequently, Nissol has potential applications in treating neurological and psychiatric disorders, including Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), schizophrenia, and narcolepsy.
MedKoo Cat#: 146341
Name: Nissol
CAS#: 5903-13-9
Chemical Formula: C13H12FNO
Exact Mass: 217.0903
Molecular Weight: 217.24
Elemental Analysis: C, 71.87; H, 5.57; F, 8.75; N, 6.45; O, 7.36
The following data is based on the product molecular weight 217.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
