BBDDL2204 is an EZH2 inhibitor. BBDDL2204 exhibited excellent EZH2Y641F enzymatic inhibitory activity with an IC50value of 2.5 nM. In addition, BBDDL2204 significantly reducedH3K27Me3 levels and displayed much enhanced potency in inhibiting the cell growth of KARPAS422 and Pfeiffer cells than1. Furthermore, kinetic experiments demonstrated BBDDL2204 binding to EZH2 in a SAM-noncompetitive mode.
MedKoo Cat#: 128904
Name: BBDDL-2204
CAS#: N/A
Chemical Formula: C37H47N5O5S
Exact Mass: 673.3298
Molecular Weight: 673.87
Elemental Analysis: C, 65.95; H, 7.03; N, 10.39; O, 11.87; S, 4.76
The following data is based on the product molecular weight 673.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
