THRX-144644 is a Lung-restricted ALK5 inhibitor . THRX-144644 demonstrated potent ALK5 activity in rat precision cut lung slices (PCLS; p-SMAD3 half-maximal inhibitory concentration [IC50] 141 nM .
MedKoo Cat#: 207223
Name: THRX-144644
CAS#: 2442519-59-5
Chemical Formula: C26H28ClF2N7
Exact Mass: 511.2063
Molecular Weight: 512.01
Elemental Analysis: C, 60.99; H, 5.51; Cl, 6.92; F, 7.42; N, 19.15
The following data is based on the product molecular weight 512.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
