Synonym
IMB-881; IMB881; IMB 881
IUPAC/Chemical Name
6-chloro-3-phenethyl-3,4-dihydro-2H-[1,3]oxazino[5,6-h]quinoline
InChi Key
ZYGKVGCVMPUZOC-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17ClN2O/c20-17-11-15-12-22(10-8-14-5-2-1-3-6-14)13-23-19(15)18-16(17)7-4-9-21-18/h1-7,9,11H,8,10,12-13H2
SMILES Code
ClC(C1=CC=CN=C12)=CC3=C2OCN(C3)CCC4=CC=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu C, Zhu X, Shi W, Duan Q, Yuan M, Zheng Y, Wei Y, You B, Zhang J, Si S, Li
Y. Synthesis, biological evaluation and validation of IMB-881 derivatives as
anti-Gram-negative bacterial agents. Bioorg Med Chem. 2025 Mar 1;119:118066.
doi: 10.1016/j.bmc.2025.118066. Epub 2025 Jan 7. PMID: 39798240.
2: Zhang X, Li Y, Wang W, Zhang J, Lin Y, Hong B, You X, Song D, Wang Y, Jiang
J, Si S. Identification of an anti-Gram-negative bacteria agent disrupting the
interaction between lipopolysaccharide transporters LptA and LptC. Int J
Antimicrob Agents. 2019 Apr;53(4):442-448. doi:
10.1016/j.ijantimicag.2018.11.016. Epub 2018 Nov 23. PMID: 30476569.
3: Dai X, Zhu X, Si S, Li Y, Yuan L. [Development of a BLI assay-based method
for detecting LptA/LptC interaction]. Sheng Wu Gong Cheng Xue Bao. 2021 Sep
25;37(9):3300-3309. Chinese. doi: 10.13345/j.cjb.200709. PMID: 34622637.
