MedKoo Cat#: 128851 | Name: KWR095

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KWR-095 is a WRN inhibitor with IC50 = 33 nM.

Chemical Structure

KWR095
KWR095
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128851

Name: KWR095

CAS#: N/A

Chemical Formula: C36H35ClF3N7O4

Exact Mass: 721.2391

Molecular Weight: 722.17

Elemental Analysis: C, 59.87; H, 4.89; Cl, 4.91; F, 7.89; N, 13.58; O, 8.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
KWR-095; KWR095; KWR 095
IUPAC/Chemical Name
2-(6-(4-(2-(1H-inden-7-yl)acetyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide
InChi Key
ZPBLQFCGVQXNSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C36H35ClF3N7O4/c1-2-29-32(45-15-13-44(14-16-45)31(49)19-24-7-3-5-22-6-4-8-26(22)24)34(50)47-35(42-33(43-47)23-11-17-51-18-12-23)46(29)21-30(48)41-28-10-9-25(20-27(28)37)36(38,39)40/h3-7,9-11,20H,2,8,12-19,21H2,1H3,(H,41,48)
SMILES Code
O=C1C(N2CCN(C(CC3=CC=CC4=C3CC=C4)=O)CC2)=C(CC)N(CC(NC5=CC=C(C(F)(F)F)C=C5Cl)=O)C6=NC(C7=CCOCC7)=NN61
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 722.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Moon B, Go A, Park S, Kim HJ, An D, Kim J, Lee JY, Kim JH, Hwang JY, Kim JA. Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers. Bioorg Med Chem Lett. 2025 May 1;120:130141. doi: 10.1016/j.bmcl.2025.130141. Epub 2025 Feb 15. PMID: 39956276. 2: Zeki Al Hazzouri A, Haan MN, Osypuk T, Abdou C, Hinton L, Aiello AE. Neighborhood socioeconomic context and cognitive decline among older Mexican Americans: results from the Sacramento Area Latino Study on Aging. Am J Epidemiol. 2011 Aug 15;174(4):423-31. doi: 10.1093/aje/kwr095. Epub 2011 Jun 29. PMID: 21715645; PMCID: PMC3159426.