YDR1 | SMARCA2 degrader

MedKoo Cat#: 128833 | Name: YDR1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YDR1 is a potent SMARCA2 degrader.

Chemical Structure

YDR1

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128833

Name: YDR1

CAS#: N/A

Chemical Formula: C44H49FN10O5

Exact Mass: 816.3871

Molecular Weight: 816.94

Elemental Analysis: C, 64.69; H, 6.05; F, 2.33; N, 17.15; O, 9.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

YDR1; YDR-1; YDR 1

IUPAC/Chemical Name

5-(4-((1-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)-2-fluorophenyl)piperidin-4-yl)methyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

InChi Key

NKECFXWADFBMPA-UHFFFAOYSA-N

InChi Code

InChI=1S/C44H49FN10O5/c45-34-23-29(27-51-17-21-54(22-18-51)38-25-35(48-49-41(38)46)32-3-1-2-4-39(32)56)5-8-36(34)53-13-11-28(12-14-53)26-50-15-19-52(20-16-50)30-6-7-31-33(24-30)44(60)55(43(31)59)37-9-10-40(57)47-42(37)58/h1-8,23-25,28,37,56H,9-22,26-27H2,(H2,46,49)(H,47,57,58)

SMILES Code

O=C1CCC(N2C(C(C=CC(N3CCN(CC4CCN(C5=C(F)C=C(CN6CCN(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)CC6)C=C5)CC4)CC3)=C9)=C9C2=O)=O)C(N1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 816.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hirata D, Yano K, Miyahara K, Miyakawa T. Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr Genet. 1994 Oct;26(4):285-94. doi: 10.1007/BF00310491. PMID: 7882421. 2: Kotagiri S, Wang Y, Han Y, Liang X, Blazanin N, Nguyen PK, Jiang Y, Lissanu Y. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456. doi: 10.1101/2024.08.23.608456. Update in: J Med Chem. 2025 Apr 25. doi: 10.1021/acs.jmedchem.4c02577. PMID: 39253520; PMCID: PMC11383272. 3: Kim S, Cabane K, Hampsey M, Reinberg D. Genetic analysis of the YDR1-BUR6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast. Mol Cell Biol. 2000 Apr;20(7):2455-65. doi: 10.1128/MCB.20.7.2455-2465.2000. PMID: 10713169; PMCID: PMC85436. 4: Kim S, Na JG, Hampsey M, Reinberg D. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):820-5. doi: 10.1073/pnas.94.3.820. PMID: 9023340; PMCID: PMC19597. 5: Miyahara K, Hirata D, Miyakawa T. Functional analysis of the promoter of the Saccharomyces cerevisiae multidrug resistance gene YDR1, which encodes a member of the ATP binding cassette (ABC) superfamily. Biosci Biotechnol Biochem. 1995 Jan;59(1):147-9. doi: 10.1271/bbb.59.147. PMID: 7765968. 6: Gómez-Navarro N, Jordán-Pla A, Estruch F, E Pérez-Ortín J. Defects in the NC2 repressor affect both canonical and non-coding RNA polymerase II transcription initiation in yeast. BMC Genomics. 2016 Mar 3;17:183. doi: 10.1186/s12864-016-2536-2. PMID: 26939779; PMCID: PMC4778323. 7: Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M. bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily. J Bacteriol. 1995 Mar;177(6):1536-43. doi: 10.1128/jb.177.6.1536-1543.1995. PMID: 7883711; PMCID: PMC176770. 8: Miyahara K, Hirata D, Miyakawa T. yAP-1- and yAP-2-mediated, heat shock- induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet. 1996 Jan;29(2):103-5. doi: 10.1007/BF02221572. PMID: 8821655. 9: Egner R, Mahé Y, Pandjaitan R, Kuchler K. Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol. 1995 Nov;15(11):5879-87. doi: 10.1128/MCB.15.11.5879. PMID: 7565740; PMCID: PMC230839.