MedKoo Cat#: 128821 | Name: GSN03126
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSN03126, also named as 5-Me-3’-dU-2’-phosphoramidite, is a nucleoside building block.

Chemical Structure

GSN03126
GSN03126
CAS#142103-12-6

Theoretical Analysis

MedKoo Cat#: 128821

Name: GSN03126

CAS#: 142103-12-6

Chemical Formula: C40H49N4O8P

Exact Mass: 744.3288

Molecular Weight: 744.83

Elemental Analysis: C, 64.50; H, 6.63; N, 7.52; O, 17.18; P, 4.16

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
GSN03126; 5-Me-3’-dU-2’-phosphoramidite; 3'-Deoxy-5'-O-DMT-5-methyluridine 2'-CE Phosphoramidite
IUPAC/Chemical Name
(2R,3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChi Key
GYSQEEMWSGWZLC-SXIXUTRBSA-N
InChi Code
InChI=1S/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-36-24-35(51-38(36)43-25-29(5)37(45)42-39(43)46)26-49-40(30-12-9-8-10-13-30,31-14-18-33(47-6)19-15-31)32-16-20-34(48-7)21-17-32/h8-10,12-21,25,27-28,35-36,38H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,38+,53?/m0/s1
SMILES Code
COC1=CC=C(C(C2=CC=CC=C2)(OC[C@@H]3C[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](O3)N4C=C(C)C(NC4=O)=O)C5=CC=C(OC)C=C5)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 744.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Osawa, T., Hitomi, Y., Wakita, S., et al. Synthesis and hybridizing properties of isoDNAs including 3'-O,4'-C-ethyleneoxy-bridged 5-methyluridine derivatives. Bioorg. Med. Chem. 26(14), 3875-3881 (2018). 2. Rizzo, C.J., Dougherty, J.P., and Breslow, R. 3′-Deoxy-2′-phosphoramidites of adenosine and 5-methyluridine used for the solid phase synthesis of unnatural 3′-deoxy-2′–5″-oligonucleotides. Tetrahedron Lett. 33(29), 4129-4132 (1992).