RJG-2051 | AKR1C3 inhibitor | CAS#2851993-77-4

MedKoo Cat#: 128818 | Name: RJG-2051

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RJG-2051 is a covalent AKR1C3 inhibitor. RJG-2051 selectively engages a noncatalytic tyrosine residue (Y24) on AKR1C3. Importantly, RJG-2051 exhibited negligible cross-reactivity with AKRs or other proteins across 1800+ tyrosine and lysine sites quantified by chemical proteomics.

Chemical Structure

RJG-2051

CAS#2851993-77-4

Theoretical Analysis

MedKoo Cat#: 128818

Name: RJG-2051

CAS#: 2851993-77-4

Chemical Formula: C26H31N5O4S

Exact Mass: 509.2097

Molecular Weight: 509.63

Elemental Analysis: C, 61.28; H, 6.13; N, 13.74; O, 12.56; S, 6.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RJG-2051; RJG2051; RJG 2051

IUPAC/Chemical Name

(4-((3-cyclohexyl-1H-1,2,4-triazol-1-yl)sulfonyl)phenyl)(4-(2-methoxyphenyl)piperazin-1-yl)methanone

InChi Key

HMWIALSNZLCBBI-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H31N5O4S/c1-35-24-10-6-5-9-23(24)29-15-17-30(18-16-29)26(32)21-11-13-22(14-12-21)36(33,34)31-19-27-25(28-31)20-7-3-2-4-8-20/h5-6,9-14,19-20H,2-4,7-8,15-18H2,1H3

SMILES Code

O=S(N1C=NC(C2CCCCC2)=N1)(C3=CC=C(C(N4CCN(C5=CC=CC=C5OC)CC4)=O)C=C3)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 509.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Grams RJ, Wolfe WJ, Seal RJ, Veccia J, Hsu KL. Discovery and Optimization of a Covalent AKR1C3 Inhibitor. J Med Chem. 2025 Apr 25. doi: 10.1021/acs.jmedchem.5c00050. Epub ahead of print. PMID: 40277220.