RTICBM-262 is a CB1 allosteric modulator (pIC50 = 6.89). RTICBM-262 showed good in vitro potencies in CB1 calcium mobilization, [35S]GTPγS binding, and cAMP assays. RTICBM-262 had reasonable metabolic stability, brain penetration, and selectivity against a panel of ∼50 targets but poor solubility and high protein binding. At 5.6 mg/kg (i.p.), RTICBM-262 significantly attenuated both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity.
MedKoo Cat#: 128800
Name: RTICBM-262
CAS#: N/A
Chemical Formula: C18H14Cl2N2O2
Exact Mass: 360.0432
Molecular Weight: 361.22
Elemental Analysis: C, 59.85; H, 3.91; Cl, 19.63; N, 7.76; O, 8.86
The following data is based on the product molecular weight 361.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
