MS479 is a PROTAC degrader. MS479 recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein. MS479 effectively reduced the protein level of BRD4 short isoform in a time-, concentration-,GLP-, SPOP-, and ubiquitin-proteasome system (UPS)-dependent manner. Additionally, MS479 effectively inhibited the proliferation of colorectal cancer (CRC) cells.
MedKoo Cat#: 128798
Name: MS479
CAS#: N/A
Chemical Formula: C59H82ClN11O5S
Exact Mass: 1091.5910
Molecular Weight: 1092.89
Elemental Analysis: C, 64.84; H, 7.56; Cl, 3.24; N, 14.10; O, 7.32; S, 2.93
The following data is based on the product molecular weight 1,092.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
