MedKoo Cat#: 128792 | Name: W454

Description:

WARNING: This product is for research use only, not for human or veterinary use.

W454 is a PfATP4 inhibitor

Chemical Structure

W454
W454
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128792

Name: W454

CAS#: N/A

Chemical Formula: C19H15ClN4O2

Exact Mass: 366.0884

Molecular Weight: 366.81

Elemental Analysis: C, 62.22; H, 4.12; Cl, 9.66; N, 15.27; O, 8.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
W454; W 454; W-454
IUPAC/Chemical Name
N-(2-chlorophenyl)-2-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)acetamide
InChi Key
JEWXYXDWXQUFRB-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H15ClN4O2/c1-12-22-23-19(26-12)14-7-6-13-8-9-24(17(13)10-14)11-18(25)21-16-5-3-2-4-15(16)20/h2-10H,11H2,1H3,(H,21,25)
SMILES Code
ClC1=C(NC(CN2C(C=C(C3=NN=C(C)O3)C=C4)=C4C=C2)=O)C=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 366.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sewell KE, Gola GF, Pignataro MF, Herrera MG, Noguera ME, Olmos J, Ramírez JA, Capece L, Aran M, Santos J. Direct Cysteine Desulfurase Activity Determination by NMR and the Study of the Functional Role of Key Structural Elements of Human NFS1. ACS Chem Biol. 2023 Jul 21;18(7):1534-1547. doi: 10.1021/acschembio.3c00147. Epub 2023 Jul 6. PMID: 37410592. 2: Guercia E, Berti F, De Zorzi R, Navarini L, Geremia S, Medagli B, De Conto M, Cassetta A, Forzato C. On the Cholesterol Raising Effect of Coffee Diterpenes Cafestol and 16-O-Methylcafestol: Interaction with Farnesoid X Receptor. Int J Mol Sci. 2024 May 31;25(11):6096. doi: 10.3390/ijms25116096. PMID: 38892285; PMCID: PMC11173301. 3: Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep- Oct;74(1-2):186-99. doi: 10.1006/mgme.2001.3212. PMID: 11592815. 4: Furuya K, Yasumori K, Takeo S, Sakino I, Uesugi N, Momosaki S, Muranaka T. Lung CT: Part 1, Mimickers of lung cancer--spectrum of CT findings with pathologic correlation. AJR Am J Roentgenol. 2012 Oct;199(4):W454-63. doi: 10.2214/AJR.10.7262. PMID: 22997395. 5: Dealwis CG, Chen L, Brennan C, Mandecki W, Abad-Zapatero C. 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity. Protein Eng. 1995 Sep;8(9):865-71. doi: 10.1093/protein/8.9.865. PMID: 8746724. 6: Zheng W, Wuyun Q, Zhou X, Li Y, Freddolino PL, Zhang Y. LOMETS3: integrating deep learning and profile alignment for advanced protein template recognition and function annotation. Nucleic Acids Res. 2022 Jul 5;50(W1):W454-W464. doi: 10.1093/nar/gkac248. PMID: 35420129; PMCID: PMC9252734. 7: Gao B, Lv C. Central-variant posterior reversible encephalopathy syndrome: more than meets the eye. AJR Am J Roentgenol. 2014 Oct;203(4):W454. doi: 10.2214/AJR.14.12671. PMID: 25247980. 8: Poliakov E, Gentleman S, Chander P, Cunningham FX Jr, Grigorenko BL, Nemuhin AV, Redmond TM. Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase. BMC Biochem. 2009 Dec 14;10:31. doi: 10.1186/1471-2091-10-31. PMID: 20003456; PMCID: PMC2801523. 9: Shaw TI, Zhang M. HIV N-linked glycosylation site analyzer and its further usage in anchored alignment. Nucleic Acids Res. 2013 Jul;41(Web Server issue):W454-8. doi: 10.1093/nar/gkt472. Epub 2013 Jun 8. PMID: 23748959; PMCID: PMC3692120.