S-WJM992 | PfATP4 inhibitor

MedKoo Cat#: 128791 | Name: S-WJM992

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S-WJM992 is a PfATP4 inhibitor.

Chemical Structure

S-WJM992

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128791

Name: S-WJM992

CAS#: N/A

Chemical Formula: C22H18ClFN6O3

Exact Mass: 468.1113

Molecular Weight: 468.87

Elemental Analysis: C, 56.36; H, 3.87; Cl, 7.56; F, 4.05; N, 17.92; O, 10.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

S-WJM992; SWJM992; S WJM992

IUPAC/Chemical Name

(R)-N-(5-chloropyridin-3-yl)-6-fluoro-4-methyl-8-(1-methyl-1H-pyrazol-4-yl)-1,5-dioxo-2,3,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3a(1H)-carboxamide

InChi Key

FXTOIXOMBUVTTG-JOCHJYFZSA-N

InChi Code

InChI=1S/C22H18ClFN6O3/c1-28-11-13(8-26-28)12-5-16(24)19-17(6-12)30-18(31)3-4-22(30,29(2)20(19)32)21(33)27-15-7-14(23)9-25-10-15/h5-11H,3-4H2,1-2H3,(H,27,33)/t22-/m1/s1

SMILES Code

CN1N=CC(C2=CC(N(C(CC3)=O)[C@]3(C(NC4=CC(Cl)=CN=C4)=O)N(C)C5=O)=C5C(F)=C2)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 468.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Ashton TD, Calic PPS, Dans MG, Ooi ZK, Zhou Q, Palandri J, Loi K, Jarman KE, Qiu D, Lehane AM, Maity BC, De N, Giannangelo C, MacRaild CA, Creek DJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Famodimu MT, Delves MJ, Pollard H, Sutherland CJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4. J Med Chem. 2024 Aug 22;67(16):14493-14523. doi: 10.1021/acs.jmedchem.4c01241. Epub 2024 Aug 12. PMID: 39134060; PMCID: PMC11345840.