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MedKoo Cat#: 146271 | Name: Pyraflufen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyraflufen is a fast-acting herbicide used primarily for the control of broadleaf weeds and some grasses in agricultural and non-crop settings. It functions as a protoporphyrinogen oxidase (PPO) inhibitor, disrupting chlorophyll synthesis and causing the rapid buildup of reactive oxygen species in plant cells. This leads to cell membrane damage, desiccation, and ultimately plant death, often visible within hours of application. Pyraflufen is commonly used in pre-plant burndown applications and as a desiccant in crops like cotton and potatoes.

Chemical Structure

Pyraflufen
Pyraflufen
CAS#129630-17-7

Theoretical Analysis

MedKoo Cat#: 146271

Name: Pyraflufen

CAS#: 129630-17-7

Chemical Formula: C13H9Cl2F3N2O4

Exact Mass: 383.9891

Molecular Weight: 385.12

Elemental Analysis: C, 40.54; H, 2.36; Cl, 18.41; F, 14.80; N, 7.27; O, 16.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pyraflufen;
IUPAC/Chemical Name
2-(2-chloro-5-(4-chloro-5-(difluoromethoxy)-1-methyl-1H-pyrazol-3-yl)-4-fluorophenoxy)acetic acid
InChi Key
YXIIPOGUBVYZIW-UHFFFAOYSA-N
InChi Code
1S/C13H9Cl2F3N2O4/c1-20-12(24-13(17)18)10(15)11(19-20)5-2-8(23-4-9(21)22)6(14)3-7(5)16/h2-3,13H,4H2,1H3,(H,21,22)
SMILES Code
CN1N=C(C(Cl)=C1OC(F)F)C2=C(F)C=C(Cl)C(OCC(O)=O)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang HL, Li JZ, Hu JY. Pyraflufen-ethyl residues in soil by solid phase extraction and high-performance liquid chromatography with UV detection. Anal Sci. 2006 Dec;22(12):1589-92. doi: 10.2116/analsci.22.1589. PMID: 17159321. 2: European Food Safety Authority (EFSA). Lack of confirmatory data following Article 12 MRL reviews for 2,4-DB, iodosulfuron-methyl, mesotrione, methoxyfenozide and pyraflufen-ethyl. EFSA J. 2023 May 16;21(5):e08013. doi: 10.2903/j.efsa.2023.8013. PMID: 37200853; PMCID: PMC10186194. 3: European Food Safety Authority (EFSA); Brancato A, Brocca D, Carrasco Cabrera L, De Lentdecker C, Erdos Z, Ferreira L, Greco L, Jarrah S, Kardassi D, Leuschner R, Lostia A, Lythgo C, Medina P, Miron I, Molnar T, Pedersen R, Reich H, Sacchi A, Santos M, Stanek A, Sturma J, Tarazona J, Theobald A, Vagenende B, Villamar-Bouza L. Evaluation of confirmatory data following the Article 12 MRL review for pyraflufen-ethyl. EFSA J. 2018 Oct 19;16(10):e05444. doi: 10.2903/j.efsa.2018.5444. PMID: 32625723; PMCID: PMC7009693. 4: Zhao LX, Chen KY, Zhao HY, Zou YL, Gao S, Fu Y, Ye F. Design, synthesis and biological activity determination of novel phenylpyrazole protoporphyrinogen oxidase inhibitor herbicides. Pestic Biochem Physiol. 2023 Nov;196:105588. doi: 10.1016/j.pestbp.2023.105588. Epub 2023 Aug 25. PMID: 37945239. 5: Tahmasebi BK, Alcántara-de la Cruz R, Alcántara E, Torra J, Domínguez- Valenzuela JA, Cruz-Hipólito HE, Rojano-Delgado AM, De Prado R. Multiple Resistance Evolution in Bipyridylium-Resistant Epilobium ciliatum After Recurrent Selection. Front Plant Sci. 2018 May 28;9:695. doi: 10.3389/fpls.2018.00695. PMID: 29892306; PMCID: PMC5985439. 6: Zhao LX, Chen KY, He XL, Zou YL, Gao S, Fu Y, Ye F. Design, Synthesis, and Biological Activity Determination of Novel Phenylpyrazole Protoporphyrinogen Oxidase Inhibitor Herbicides Containing Five-Membered Heterocycles. J Agric Food Chem. 2023 Oct 4;71(39):14164-14178. doi: 10.1021/acs.jafc.3c03108. Epub 2023 Sep 21. PMID: 37732717. 7: Wang Y, Wu S, Chen L, Wu C, Yu R, Wang Q, Zhao X. Toxicity assessment of 45 pesticides to the epigeic earthworm Eisenia fetida. Chemosphere. 2012 Jul;88(4):484-91. doi: 10.1016/j.chemosphere.2012.02.086. Epub 2012 Mar 28. PMID: 22459421. 8: Xu D, Lu S, Chen D, Lan J, Zhang Z, Yang F, Zhou Y. [Determination of ten pesticides of pyrazoles and pyrroles in tea by accelerated solvent extraction coupled with gas chromatography-tandem mass spectrometry]. Se Pu. 2013 Mar;31(3):218-22. Chinese. doi: 10.3724/sp.j.1123.2012.10003. PMID: 23785993. 9: Mattison RL, Beffa R, Bojack G, Bollenbach-Wahl B, Dörnbrack C, Dorn N, Freigang J, Gatzweiler E, Getachew R, Hartfiel C, Heinemann I, Helmke H, Hohmann S, Jakobi H, Lange G, Lümmen P, Willms L, Frackenpohl J. Design, synthesis and screening of herbicidal activity for new phenyl pyrazole-based protoporphyrinogen oxidase-inhibitors (PPO) overcoming resistance issues. Pest Manag Sci. 2023 Jun;79(6):2264-2280. doi: 10.1002/ps.7425. Epub 2023 Mar 8. PMID: 36815643. 10: Subedi M, Willenborg CJ, Vandenberg A. Influence of Harvest Aid Herbicides on Seed Germination, Seedling Vigor and Milling Quality Traits of Red Lentil (Lens culinaris L.). Front Plant Sci. 2017 Mar 14;8:311. doi: 10.3389/fpls.2017.00311. PMID: 28352275; PMCID: PMC5349153.