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MedKoo Cat#: 128784 | Name: YZ-836P

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YZ-836P is PRMT5 inhibitor and degrader.

Chemical Structure

YZ-836P
YZ-836P
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128784

Name: YZ-836P

CAS#: N/A

Chemical Formula: C45H57N9O7

Exact Mass: 835.4381

Molecular Weight: 836.01

Elemental Analysis: C, 64.65; H, 6.87; N, 15.08; O, 13.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
YZ-836P; YZ836P; YZ 836P
IUPAC/Chemical Name
N-((S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-(10-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)decanoyl)piperidin-4-yl)amino)pyrimidine-4-carboxamide
InChi Key
UCFDBEXRDDHPKD-OEEKEXDXSA-N
InChi Code
InChI=1S/C45H57N9O7/c55-34(28-52-21-17-30-10-7-8-11-31(30)27-52)26-47-42(58)37-25-39(49-29-48-37)50-32-18-22-53(23-19-32)41(57)12-6-4-2-1-3-5-9-20-46-33-13-14-35-36(24-33)45(61)54(44(35)60)38-15-16-40(56)51-43(38)59/h7-8,10-11,13-14,24-25,29,32,34,38,46,55H,1-6,9,12,15-23,26-28H2,(H,47,58)(H,48,49,50)(H,51,56,59)/t34-,38?/m0/s1
SMILES Code
O=C(C1=CC(NC2CCN(C(CCCCCCCCCNC3=CC=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=C3)=O)CC2)=NC=N1)NC[C@H](O)CN(CC6)CC7=C6C=CC=C7
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 836.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Guo Y, Li Y, Zhou Z, Hou L, Liu W, Ren W, Mi D, Sun J, Dai X, Wu Y, Cheng Z, Wu T, Luo Q, Tian C, Li F, Yu Z, Chen Y, Chen C. Targeting PRMT5 through PROTAC for the treatment of triple-negative breast cancer. J Exp Clin Cancer Res. 2024 Nov 30;43(1):314. doi: 10.1186/s13046-024-03237-y. PMID: 39614393; PMCID: PMC11607928.