MedKoo Cat#: 146254 | Name: Fluxofenim

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluxofenim is a herbicide safener used to protect crops like maize and sorghum from damage caused by certain pre-emergence herbicides, especially those in the chloroacetanilide and thiocarbamate families. It functions by stimulating the plant’s detoxification pathways, particularly through the activation of enzymes like glutathione S-transferases (GSTs), which metabolize and neutralize herbicide compounds. By enhancing the crop's tolerance, fluxofenim enables the use of effective herbicides without affecting crop health. It is typically applied as a seed treatment or in combination with herbicides.

Chemical Structure

Fluxofenim
Fluxofenim
CAS#88485-37-4

Theoretical Analysis

MedKoo Cat#: 146254

Name: Fluxofenim

CAS#: 88485-37-4

Chemical Formula: C12H11ClF3NO3

Exact Mass: 309.0380

Molecular Weight: 309.67

Elemental Analysis: C, 46.54; H, 3.58; Cl, 11.45; F, 18.41; N, 4.52; O, 15.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fluxofenim;
IUPAC/Chemical Name
(E)-1-(4-chlorophenyl)-2,2,2-trifluoroethan-1-one O-((1,3-dioxolan-2-yl)methyl) oxime
InChi Key
UKSLKNUCVPZQCQ-GZTJUZNOSA-N
InChi Code
1S/C12H11ClF3NO3/c13-9-3-1-8(2-4-9)11(12(14,15)16)17-20-7-10-18-5-6-19-10/h1-4,10H,5-7H2/b17-11+
SMILES Code
FC(F)(F)C(=NOCC1OCCO1)C2=CC=C(Cl)C=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shi Y, Wang J, Wang Z, Jiao Z, Du Q, Jia X, Niu J, Du R, Ji G, Duan P, Lv P, Cao J. Integrating transcriptome and physiological analyses to elucidate the molecular responses of sorghum to fluxofenim and metolachlor herbicide. Pestic Biochem Physiol. 2023 Dec;197:105692. doi: 10.1016/j.pestbp.2023.105692. Epub 2023 Nov 14. PMID: 38072547. 2: Scarponi L, Quagliarini E, Del Buono D. Induction of wheat and maize glutathione S-transferase by some herbicide safeners and their effect on enzyme activity against butachlor and terbuthylazine. Pest Manag Sci. 2006 Oct;62(10):927-32. doi: 10.1002/ps.1258. PMID: 16835885. 3: Baek YS, Goodrich LV, Brown PJ, James BT, Moose SP, Lambert KN, Riechers DE. Transcriptome Profiling and Genome-Wide Association Studies Reveal GSTs and Other Defense Genes Involved in Multiple Signaling Pathways Induced by Herbicide Safener in Grain Sorghum. Front Plant Sci. 2019 Mar 8;10:192. doi: 10.3389/fpls.2019.00192. PMID: 30906302; PMCID: PMC6418823. 4: Scarponi L, Del Buono D. Festuca arundinacea, glutathione S-transferase and herbicide safeners: a preliminary case study to reduce herbicidal pollution. J Environ Sci Health B. 2009 Nov;44(8):805-9. doi: 10.1080/03601230903238400. PMID: 20183093. 5: DeRidder BP, Dixon DP, Beussman DJ, Edwards R, Goldsbrough PB. Induction of glutathione S-transferases in Arabidopsis by herbicide safeners. Plant Physiol. 2002 Nov;130(3):1497-505. doi: 10.1104/pp.010066. PMID: 12428014; PMCID: PMC166668. 6: DeRidder BP, Goldsbrough PB. Organ-specific expression of glutathione S-transferases and the efficacy of herbicide safeners in Arabidopsis. Plant Physiol. 2006 Jan;140(1):167-75. doi: 10.1104/pp.105.067199. Epub 2005 Dec 16. PMID: 16361527; PMCID: PMC1326041. 7: Riechers DE, Irzyk GP, Jones SS, Fuerst EP. Partial characterization of glutathione S-transferases from wheat (Triticum spp.) and purification of a safener-induced glutathione S-transferase from Triticum tauschii. Plant Physiol. 1997 Aug;114(4):1461-70. doi: 10.1104/pp.114.4.1461. PMID: 9276955; PMCID: PMC158439. 8: Ueda N, Yoshimura R, Shinkai K, Sakata Y, Nakamura J. Higher plasma 5-hydroxyindoleacetic acid levels are associated with SSRI-induced nausea. Neuropsychobiology. 2003;48(1):31-4. doi: 10.1159/000071826. PMID: 12886038. 9: Zhang Q, Riechers DE. Proteomic characterization of herbicide safener-induced proteins in the coleoptile of Triticum tauschii seedlings. Proteomics. 2004 Jul;4(7):2058-71. doi: 10.1002/pmic.200300733. PMID: 15221767. 10: Rishi AS, Munir S, Kapur V, Nelson ND, Goyal A. Identification and analysis of safener-inducible expressed sequence tags in Populus using a cDNA microarray. Planta. 2004 Dec;220(2):296-306. doi: 10.1007/s00425-004-1356-9. Epub 2004 Sep 18. PMID: 15378367. 11: Riechers DE, Zhang Q, Xu F, Vaughn KC. Tissue-specific expression and localization of safener-induced glutathione S-transferase proteins in Triticum tauschii. Planta. 2003 Sep;217(5):831-40. doi: 10.1007/s00425-003-1063-y. Epub 2003 Jun 24. PMID: 12827355.