Synonym
TMPO; M4PO; NSC 78027;
IUPAC/Chemical Name
2,2,4,4-tetramethyl-3,4-dihydro-2H-pyrrole 1-oxide
InChi Key
GUQARRULARNYQZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H15NO/c1-7(2)5-8(3,4)9(10)6-7/h6H,5H2,1-4H3
SMILES Code
[O-][N+]1=CC(C)(C)CC1(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
141.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Buettner, G.R., and Britigan, B.E. The spin trapping of superoxide with M4PO (3,3,5,5-Tetramethylpyrroline-N-oxide). Free Radic. Biol. Med. 8(1), 57-60 (1990).
2. Davies, M.J., Forni, L.G., and Shuter, S.L. Electron spin resonance and pulse radiolysis studies on the spin trapping of sulphur-centered radicals. Chem. Biol. Interact. 61(2), 177-188 (1987).
3. Slater, A.F., Nobel, C.S., Maellaro, E., et al. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem. J. 306(Pt 3)(Pt 3), 771-778 (1995).
