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MedKoo Cat#: 146223 | Name: Dimephosphon

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimephosphon is an organophosphorus compound known for its anti-inflammatory and immunomodulatory properties. It has been explored for medical applications, particularly in the treatment of inflammatory conditions and certain autoimmune disorders. The mechanism of action involves modulation of immune cell activity and inhibition of pro-inflammatory mediators, potentially through interference with phosphonate-related metabolic pathways. Due to its chemical structure, Dimephosphon may also influence bone metabolism, making it of interest in the context of bone-related diseases.

Chemical Structure

Dimephosphon
CAS#14394-26-4

Theoretical Analysis

MedKoo Cat#: 146223

Name: Dimephosphon

CAS#: 14394-26-4

Chemical Formula: C8H17O4P

Exact Mass: 208.0864

Molecular Weight: 208.19

Elemental Analysis: C, 46.15; H, 8.23; O, 30.74; P, 14.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dimephosphon; Dimephosphone;
IUPAC/Chemical Name
dimethyl (2-methyl-4-oxopentan-2-yl)phosphonate
InChi Key
MOMJYWJXUNIBGJ-UHFFFAOYSA-N
InChi Code
1S/C8H17O4P/c1-7(9)6-8(2,3)13(10,11-4)12-5/h6H2,1-5H3
SMILES Code
COP(=O)(OC)C(C)(C)CC(C)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 208.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Eremeev AM, Tumakaev RF, Yafarova GG, Ibragimov YKh, Pleshchinskii IN. Effect of dimephosphon on functional recovery of damaged spinal cord. Bull Exp Biol Med. 2006 Feb;141(2):181-3. doi: 10.1007/s10517-006-0122-3. PMID: 16984091. 2: Khafiz'yanova RKh, Mukhutdinov DA. Effect of dimephosphon on lymph circulation and microcirculation, contractility of the wall and cusps of valves in lymphatic microvessels, and cell composition of the lymph during fever. Bull Exp Biol Med. 2005 Jun;139(6):680-2. doi: 10.1007/s10517-005-0377-0. PMID: 16224580. 3: Penionzhkevich DIu, Gorbunov FE, Oganesian VR. Dimefosfon-élektroforez sinusoidal'nymi modulirovannymi tokami kak novyĭ metod fizioterapii v klinicheskoĭ praktike [Dimephosphon-electrophoresis with sinusoidal modulated currents as a new method of physiotherapy in clinical practice]. Vopr Kurortol Fizioter Lech Fiz Kult. 2004 Jan-Feb;(1):28-30. Russian. PMID: 15052843. 4: Burykin IM, Aleeva GN, Khafiz'ianova RKh. Vvedenie dimefosfona v rannie sroki beremennnosti i otsenka ego deĭstviia na potomstvo krys [Introduction of dimephosphon in the early stage of pregnancy and its effect on the rat progeny]. Eksp Klin Farmakol. 2004 Mar-Apr;67(2):35-7. Russian. PMID: 15188758. 5: Ziganshina LE, Burnashova ZA, Valeeva IKh, Salikhov IG, Tsyplakov DE, Galiautdinova AIu, Garifullova IuV, Valiev VS. Sravnitel'noe izuchenie vliianiia monofosfonata dimefosfona i bifosfonata ksidifona na gistomorfometricheskie pokazateli stroeniia pozvonkov krys pri modelirovanii gliukokortikosteroidnogo osteoporoza [Comparative study of the effect of dimephosphon monophosphonate and xydiphone biphosphonate on the histomorphometric indices of rat vertebra in a model of glucocorticosteroid osteoporosis]. Eksp Klin Farmakol. 2002 Sep- Oct;65(5):62-5. Russian. PMID: 12596520. 6: Ziganshina LE, Studentsova IA, Ziganshin AU. Eksperimental'noe obosnovanie kombinirovannogo primeneniia dimefosfona s nesteroidnymi protivovospalitel'nymi preparatami [An experimental validation of the combined use of dimephosphon with nonsteroidal anti-inflammatory preparations]. Eksp Klin Farmakol. 1992 May- Jun;55(3):44-6. Russian. PMID: 1458163. 7: Khafiz'yanova RKh, Aleyeva GN, Mukhutdinov DA. Lymphotropic effect of dimephosphon, mexidol, and ketorolac is realized via activation of the lymphangion and stimulation of lymph formation. Bull Exp Biol Med. 2007 Apr;143(4):446-8. doi: 10.1007/s10517-007-0152-5. PMID: 18214296. 8: Tumakaev RF, Guseva DS, Garaev RS. [Dimephosphon restores functions of the injured spinal cord]. Eksp Klin Farmakol. 2010 May;73(5):41-4. Russian. PMID: 20597371. 9: Ziganshina LE, Studentsova IA, Zaikonnikova IV. Vliianie dimefosfona na vospalitel'nuiu reaktsiiu [Effect of dimephosphon on the inflammatory reaction]. Farmakol Toksikol. 1988 May-Jun;51(3):58-60. Russian. PMID: 3410029. 10: Berkhin EB, Lampatov VV, Ul'ianov GP. Vliianie 5-oksimetiluratsila i dimefosfona na kanal'tsevuiu sekretsiiu ksenobiotikov v pochke [Effect of 5-hydroxymethyluracil and dimephosphon on the tubular secretion of xenobiotics in the kidney]. Farmakol Toksikol. 1987 Sep-Oct;50(5):37-8. Russian. PMID: 3691775. 11: Ziganshina LE, Burnasheva ZA, Valeeva IKh, Galiautdinova AIu, Samoĭlova NS. Sravnitel'noe izuchenie éffektivnosti dimefosfona i ksidifona pri steroidnom osteoporoze u krys [Comparative study of dimephosphon and xidiphone efficacy in steroid-induced osteoporosis in rats]. Eksp Klin Farmakol. 2000 Nov- Dec;63(6):39-42. Russian. PMID: 11202511. 12: Svatko LG, Chepepnev GV, Rafailov VV. Immunnyĭ status bol'nykh ékssudativnym srednim otitom do i posle lecheniia dimefosfonom [Immune status of patients with exudative otitis media before and after dimephosphon treatment]. Vestn Otorinolaringol. 2001;(1):8-11. Russian. PMID: 11247256. 13: Valeeva IKh, Titarenko AF, Ziganshina LE. [Comparative analysis of dimephosphon, ionol, and xydiphone effects on indomethacin-induced gastric lesions in rats]. Eksp Klin Farmakol. 2010 Dec;73(12):21-4. Russian. PMID: 21395012. 14: Danilov VI, Gorozhanin AV, Studentsova IA. Vliianie dimefosfona, sermiona i piratsetama na reaktivnost' mozgovykh sosudov, lokal'nyĭ mozgovoĭ krovotok i napriazhenie kisloroda v tkani golovnogo mozga [The effect of dimephosphon, sermion and piracetam on the reactivity of the cerebral vessels, on local cerebral blood flow and on oxygen tension in brain tissue]. Eksp Klin Farmakol. 1994 Mar-Apr;57(2):19-22. Russian. PMID: 8205041. 15: Pikuza OI, Zaikonnikova IV, Studentsova IA, Aleksandrova LIa. Opyt primeneniia dimefosfona v kompleksnoĭ terapii pnevmonii u novorozhdennykh deteĭ [Experience using dimephosphon in the complex treatment of pneumonia in newborn infants]. Pediatriia. 1989;(3):39-41. Russian. PMID: 2542878. 16: Ziganshina LE, Studentsova IA, Zaikonnikova IV, Ziganshin AU, Popova LG. Vliianie dimefosfona na protsessy ékssudatsii i proliferatsii [The effect of dimephosphon on exudative and proliferative processes]. Farmakol Toksikol. 1990 Jan-Feb;53(1):57-9. Russian. PMID: 2328804. 17: Aleksandrova AE, Shcherbakova NM, Zabolotnykh NV, Shchegoleva RA. Ispol'zovanie dimefosfona v kachestve sredstva patogeneticheskoĭ terapii éksperimental'nogo tuberkuleza [Use of dimephosphon in pathogenetic therapy of experimental tuberculosis]. Probl Tuberk. 1991;(8):68-71. Russian. PMID: 1758864. 18: Vizel' AA. Dimefosfon v korrektsii narusheniĭ funktsii vneshnego dykhaniia pri tuberkuleze legkikh [Use of dimephosphon for correction of functional disorders of external respiration in pulmonary tuberculosis]. Sov Med. 1991;(9):60-2. Russian. PMID: 1798928. 19: Ziganshin AU, Studentsova IA, Zaikonnikova IV. Vliianie dimefosfona na sistemu adenilovykh nukleotidov [Effect of dimephosphon on the adenine nucleotide system]. Farmakol Toksikol. 1988 Jul-Aug;51(4):80-2. Russian. PMID: 3191981. 20: Sviatkina OB, Pogomiĭ NN, Kruglyĭ BI, Tuluevskaia LM, Basova EN. Antiallergicheskoe deĭstvie dimefosfona i ego ispol'zovanie dlia lecheniia atopicheskoĭ bronkhial'noĭ astmy i pollinoza u deteĭ [Antiallergic action of dimephosphon and its use in the treatment of atopic bronchial asthma and pollinosis in children]. Pediatriia. 1989;(1):85-8. Russian. PMID: 2710612.