MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 146188 | Name: Aloesone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aloesone is a naturally occurring compound found in Aloe species, particularly known for its antimicrobial and anti-inflammatory properties. It functions partly by inhibiting bacterial growth and modulating inflammatory pathways, although its exact molecular targets are still being investigated. Aloesone has shown potential in treating skin infections and promoting wound healing due to these bioactivities. Its presence contributes to the medicinal value of aloe-based topical and therapeutic formulations.

Chemical Structure

Aloesone
Aloesone
CAS#40738-40-7

Theoretical Analysis

MedKoo Cat#: 146188

Name: Aloesone

CAS#: 40738-40-7

Chemical Formula: C13H12O4

Exact Mass: 232.0736

Molecular Weight: 232.24

Elemental Analysis: C, 67.23; H, 5.21; O, 27.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Aloesone;
IUPAC/Chemical Name
7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-chromen-4-one
InChi Key
JHELBXAAAYUKCT-UHFFFAOYSA-N
InChi Code
1S/C13H12O4/c1-7-3-9(15)5-12-13(7)11(16)6-10(17-12)4-8(2)14/h3,5-6,15H,4H2,1-2H3
SMILES Code
CC(=O)CC1=CC(=O)C2=C(O1)C=C(O)C=C2C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 232.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Putkaradze N, Dato L, Kırtel O, Hansen J, Welner DH. Enzymatic glycosylation of aloesone performed by plant UDP-dependent glycosyltransferases. Glycobiology. 2024 Jul 26;34(9):cwae050. doi: 10.1093/glycob/cwae050. PMID: 38995933; PMCID: PMC11273223. 2: Wang Y, Xiong Z, Li C, Liu D, Li X, Xu J, Chen N, Wang X, Li Q, Li Y. Multiple Beneficial Effects of Aloesone from Aloe vera on LPS-Induced RAW264.7 Cells, Including the Inhibition of Oxidative Stress, Inflammation, M1 Polarization, and Apoptosis. Molecules. 2023 Feb 8;28(4):1617. doi: 10.3390/molecules28041617. PMID: 36838606; PMCID: PMC9960963. 3: Ren X, Wang Z, Wang X, Li Y, Tan Y. Determination of aloesone in rat plasma by LC-MS/MS spectrometry and its application in a pharmacokinetic study. Bioanalysis. 2024;16(10):453-460. doi: 10.4155/bio-2023-0231. Epub 2024 Mar 18. PMID: 38497753; PMCID: PMC11216510. 4: Wang Y, Li C, Xiong Z, Chen N, Wang X, Xu J, Wang Y, Liu L, Wu H, Huang C, Huang A, Tan J, Li Y, Li Q. Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models. Front Pharmacol. 2022 Aug 12;13:962223. doi: 10.3389/fphar.2022.962223. PMID: 36034878; PMCID: PMC9411719. 5: Holdsworth DK. Chromones in aloe species. II. Aloesone. Planta Med. 1972 Aug;22(1):54-8. doi: 10.1055/s-0028-1099582. PMID: 5083248. 6: Abe I, Watanabe T, Lou W, Noguchi H. Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase. FEBS J. 2006 Jan;273(1):208-18. doi: 10.1111/j.1742-4658.2005.05059.x. PMID: 16367761. 7: Liu AJ, Xie KB, Liu YY, Sui SY, Chen RD, Chen DW, Liu JM, Yang L, Dai JG. Biosynthesis of polyketides by two type III polyketide synthases from Aloe barbadensis. J Asian Nat Prod Res. 2020 May;22(5):434-443. doi: 10.1080/10286020.2019.1674287. Epub 2019 Dec 3. PMID: 31791147. 8: Yang D, Kim WJ, Yoo SM, Choi JH, Ha SH, Lee MH, Lee SY. Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9835-9844. doi: 10.1073/pnas.1808567115. Epub 2018 Sep 19. PMID: 30232266; PMCID: PMC6176597. 9: Shlyk NP, Yurchenko EA, Leshchenko EV, Chingizova EA, Chingizov AR, Chausova VE, Kirichuk NN, Khudyakova YV, Pivkin MV, Antonov AS, Popov RS, Isaeva MP, Yurchenko AN. The secondary metabolites of the alga-derived fungus Aspergillus niveoglaucus КММ 4176 and their antimicrobial and antibiofilm activities. J Antibiot (Tokyo). 2025 Feb 21. doi: 10.1038/s41429-025-00811-0. Epub ahead of print. PMID: 39984736. 10: Ushasree MV, Jia Q, Do SG, Lee EY. New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera. Biotechnol Adv. 2024 May-Jun;72:108325. doi: 10.1016/j.biotechadv.2024.108325. Epub 2024 Feb 21. PMID: 38395206. 11: Lucini L, Pellizzoni M, Pellegrino R, Molinari GP, Colla G. Phytochemical constituents and in vitro radical scavenging activity of different Aloe species. Food Chem. 2015 Mar 1;170:501-7. doi: 10.1016/j.foodchem.2014.08.034. Epub 2014 Aug 27. PMID: 25306376. 12: Mizuuchi Y, Shi SP, Wanibuchi K, Kojima A, Morita H, Noguchi H, Abe I. Novel type III polyketide synthases from Aloe arborescens. FEBS J. 2009 Apr;276(8):2391-401. doi: 10.1111/j.1742-4658.2009.06971.x. PMID: 19348024. 13: Che QM, Akao T, Hattori M, Kobashi K, Namba T. Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain. Chem Pharm Bull (Tokyo). 1991 Mar;39(3):704-8. doi: 10.1248/cpb.39.704. PMID: 2070451. 14: Abe I, Utsumi Y, Oguro S, Noguchi H. The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide. FEBS Lett. 2004 Mar 26;562(1-3):171-6. doi: 10.1016/S0014-5793(04)00230-3. PMID: 15044020. 15: Karppinen K, Hokkanen J, Mattila S, Neubauer P, Hohtola A. Octaketide- producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins. FEBS J. 2008 Sep;275(17):4329-42. doi: 10.1111/j.1742-4658.2008.06576.x. Epub 2008 Jul 21. PMID: 18647343. 16: Reza Nazifi SM, Asgharshamsi MH, Dehkordi MM, Zborowski KK. Antioxidant properties of Aloe vera components: a DFT theoretical evaluation. Free Radic Res. 2019 Aug;53(8):922-931. doi: 10.1080/10715762.2019.1648798. Epub 2019 Aug 14. PMID: 31357895.