Spinacetin | CAS#3153-83-1 | flavonoid

MedKoo Cat#: 146185 | Name: Spinacetin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Spinacetin is a flavonoid compound found in spinach (Spinacia oleracea) and other green leafy vegetables, known for its antioxidant and anti-inflammatory properties. It functions by scavenging reactive oxygen species (ROS) and modulating key signaling pathways such as NF-κB and MAPK, which are involved in inflammation and cellular stress responses. Spinacetin has been studied for its potential in preventing chronic diseases related to oxidative stress, including cardiovascular disorders and certain cancers. Its natural origin and bioactivity make it a promising candidate for nutraceutical and therapeutic applications.

Chemical Structure

Spinacetin

CAS#3153-83-1

Theoretical Analysis

MedKoo Cat#: 146185

Name: Spinacetin

CAS#: 3153-83-1

Chemical Formula: C21H20O11

Exact Mass: 448.1006

Molecular Weight: 448.38

Elemental Analysis: C, 56.25; H, 4.50; O, 39.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Spinacetin;

IUPAC/Chemical Name

3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one

InChi Key

XWIDINOKCRFVHQ-UHFFFAOYSA-N

InChi Code

1S/C17H14O8/c1-23-10-5-7(3-4-8(10)18)16-15(22)13(20)12-11(25-16)6-9(19)17(24-2)14(12)21/h3-6,18-19,21-22H,1-2H3

SMILES Code

COC1=CC(=CC=C1O)C2=C(O)C(=O)C3=C(O2)C=C(O)C(OC)=C3O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 448.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu D, Zhao L. Spinacetin alleviates doxorubicin-induced cardiotoxicity by initiating protective autophagy through SIRT3/AMPK/mTOR pathways. Phytomedicine. 2022 Jul;101:154098. doi: 10.1016/j.phymed.2022.154098. Epub 2022 Apr 12. PMID: 35430482. 2: Ji N, Pan S, Shao C, Chen Y, Zhang Z, Wang R, Qiu Y, Jin M, Kong D. Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model. Front Pharmacol. 2018 Jul 30;9:824. doi: 10.3389/fphar.2018.00824. PMID: 30104977; PMCID: PMC6077219. 3: Jose S, Devi SS, P S, Al-Khafaji K. Phytochemical constituents of Inula britannica as potential inhibitors of dihydrofolate reductase: A strategic approach against shigellosis. J Biomol Struct Dyn. 2022;40(22):11932-11947. doi: 10.1080/07391102.2021.1966508. Epub 2021 Aug 23. PMID: 34424817. 4: Kokanova-Nedialkova Z, Nedialkov P, Kondeva-Burdina M, Simeonova R, Tzankova V, Aluani D. Chenopodium bonus-henricus L. - A source of hepatoprotective flavonoids. Fitoterapia. 2017 Apr;118:13-20. doi: 10.1016/j.fitote.2017.02.001. Epub 2017 Feb 14. PMID: 28229939. 5: Jahanbani P, Nasseri S, Mojarrab M. Antioxidant Activity-guided Phytochemical Investigation of Artemisia aucheri Boiss.: Isolation of Ethyl Caffeate and a Spinacetin Glycoside. Iran J Pharm Res. 2021 Winter;20(1):82-90. doi: 10.22037/ijpr.2019.15496.13140. PMID: 34400943; PMCID: PMC8170746. 6: Pawłowska K, Czerwińska ME, Wilczek M, Strawa J, Tomczyk M, Granica S. Anti- inflammatory Potential of Flavonoids from the Aerial Parts of Corispermum marschallii. J Nat Prod. 2018 Aug 24;81(8):1760-1768. doi: 10.1021/acs.jnatprod.8b00152. Epub 2018 Aug 15. PMID: 30109803. 7: Moscatelli V, Hnatyszyn O, Acevedo C, Megías J, Alcaraz MJ, Ferraro G. Flavonoids from Artemisia copa with anti-inflammatory activity. Planta Med. 2006 Jan;72(1):72-4. doi: 10.1055/s-2005-873177. PMID: 16450301. 8: Rauf A, Rashid U, Shbeer AM, Al-Ghorbani M, Muhammad N, Khalil AA, Naz H, Sharma R, Ribaudo G. Flavonoids from Pistacia chinensis subsp. integerrima with leishmanicidal activity: computational and experimental evidence. Nat Prod Res. 2024 Sep;38(18):3282-3287. doi: 10.1080/14786419.2023.2228459. Epub 2023 Jun 26. PMID: 37357619. 9: Singh A, Singh P, Kumar B, Kumar S, Dev K, Maurya R. Detection of flavonoids from Spinacia oleracea leaves using HPLC-ESI-QTOF-MS/MS and UPLC- QqQLIT-MS/MS techniques. Nat Prod Res. 2019 Aug;33(15):2253-2256. doi: 10.1080/14786419.2018.1489395. Epub 2018 Sep 27. PMID: 30259760. 10: Singh J, Jayaprakasha GK, Patil BS. Rapid ultra-high-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry and selected reaction monitoring strategy for the identification and quantification of minor spinacetin derivatives in spinach. Rapid Commun Mass Spectrom. 2017 Nov 15;31(21):1803-1812. doi: 10.1002/rcm.7967. PMID: 28836299. 11: Gođevac D, Stanković J, Novaković M, Anđelković B, Dajić-Stevanović Z, Petrović M, Stanković M. Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity. J Nat Prod. 2015 Sep 25;78(9):2198-204. doi: 10.1021/acs.jnatprod.5b00273. Epub 2015 Aug 20. PMID: 26290401. 12: Kokanova-Nedialkova Z, Kondeva-Burdina M, Nedialkov PT. Neuroprotective, anti-α-glucosidase and prolipase active flavonoids from Good King Henry (Chenopodium bonus-henricus L.). Nat Prod Res. 2021 Dec;35(23):5484-5488. doi: 10.1080/14786419.2020.1784172. Epub 2020 Jun 27. PMID: 32597284. 13: Akdad M, Moujane S, Bouadid I, Benlyas M, Eddouks M. Phytocompounds from Anvillea radiata as promising anti-Covid-19 drugs: in silico studies and in vivo safety assessment. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2021;56(14):1512-1523. doi: 10.1080/10934529.2021.2020029. Epub 2022 Jan 2. PMID: 34978275. 14: Aljohani ASM, Alhumaydhi FA, Rauf A, Hamad EM, Rashid U. In Vivo Anti- Inflammatory, Analgesic, Sedative, Muscle Relaxant Activities and Molecular Docking Analysis of Phytochemicals from Euphorbia pulcherrima. Evid Based Complement Alternat Med. 2022 Apr 13;2022:7495867. doi: 10.1155/2022/7495867. PMID: 35722143; PMCID: PMC9205722. 15: Hemeg HA, Rauf A, Rashid U, Muhammad N, Al-Awthan YS, Bahattab OS, Al-Duais MA, Shah SUA. In Vitro α-Glycosidase Inhibition and In Silico Studies of Flavonoids Isolated from Pistacia integerrima Stew ex Brandis. Biomed Res Int. 2022 Sep 9;2022:9636436. doi: 10.1155/2022/9636436. PMID: 36119934; PMCID: PMC9481312. 16: Yuk HJ, Ryu HW, Kim DY, Park MH, Seo WD, Jeong SH, Oh SR. Comparison of flavonoid and policosanol profiles in Korean winter-spinach (Spinacia oleracea L.) cultivated in different regions. Food Chem. 2019 May 1;279:202-208. doi: 10.1016/j.foodchem.2018.11.143. Epub 2018 Dec 6. PMID: 30611481. 17: Passon M, Bühlmeier J, Zimmermann BF, Stratmann A, Latz S, Stehle P, Galensa R. Polyphenol Phase-II Metabolites are Detectable in Human Plasma after Ingestion of 13 C Labeled Spinach-a Pilot Intervention Trial in Young Healthy Adults. Mol Nutr Food Res. 2018 May;62(10):e1701003. doi: 10.1002/mnfr.201701003. Epub 2018 Apr 20. PMID: 29529352. 18: De Oliveira DB, de Almeida AP, De B A Simões GL, Auvin C, Kaiser CR, Costa SS. First isolation of a symmetrical glycosylated methylene bisflavonoid. Planta Med. 2003 Apr;69(4):382-4. doi: 10.1055/s-2003-38885. PMID: 12709912. 19: Rauf A, Rashid U, Akram Z, Ghafoor M, Muhammad N, Al Masoud N, Alomar TS, Naz S, Iriti M. In vitro and in silico antiproliferative potential of isolated flavonoids constitutes from Pistacia integerrima. Z Naturforsch C J Biosci. 2024 Apr 1;79(7-8):187-193. doi: 10.1515/znc-2023-0153. PMID: 38549290. 20: Khan J, Sakib SA, Mahmud S, Khan Z, Islam MN, Sakib MA, Emran TB, Simal- Gandara J. Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations. J Biomol Struct Dyn. 2022;40(21):10741-10752. doi: 10.1080/07391102.2021.1947893. Epub 2021 Jul 19. PMID: 34278965.