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MedKoo Cat#: 146174 | Name: Populin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Populin is a natural flavonoid glycoside found in various plant species, particularly in Populus trees. It is known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it useful in traditional medicine for treating conditions like infections and inflammatory diseases. Populin works by scavenging free radicals and inhibiting the activity of pro-inflammatory enzymes, helping to reduce oxidative stress and inflammation. Its mechanism also involves modulating immune responses, promoting tissue healing, and protecting cells from damage caused by oxidative stress.

Chemical Structure

Populin
Populin
CAS#99-17-2

Theoretical Analysis

MedKoo Cat#: 146174

Name: Populin

CAS#: 99-17-2

Chemical Formula: C16H25NO

Exact Mass: 247.1936

Molecular Weight: 247.38

Elemental Analysis: C, 77.68; H, 10.19; N, 5.66; O, 6.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Populin; Populoside;
IUPAC/Chemical Name
((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-2-yl)methyl benzoate
InChi Key
HHSKNLJWHGXWPK-BFMVXSJESA-N
InChi Code
1S/C20H22O8/c21-10-13-8-4-5-9-14(13)27-20-18(24)17(23)16(22)15(28-20)11-26-19(25)12-6-2-1-3-7-12/h1-9,15-18,20-24H,10-11H2/t15-,16-,17+,18-,20-/m1/s1
SMILES Code
OCC1=CC=CC=C1O[C@@H]2O[C@H](COC(=O)C3=CC=CC=C3)[C@@H](O)[C@H](O)[C@H]2O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 247.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baroni F, Gallo M, Pazzagli L, Luti S, Baccelli I, Spisni A, Pertinhez TA. A mechanistic model may explain the dissimilar biological efficiency of the fungal elicitors cerato-platanin and cerato-populin. Biochim Biophys Acta Gen Subj. 2021 May;1865(5):129843. doi: 10.1016/j.bbagen.2021.129843. Epub 2021 Jan 11. PMID: 33444726. 2: Martellini F, Faoro F, Carresi L, Pantera B, Baccelli I, Maffi D, Tiribilli B, Sbrana F, Luti S, Comparini C, Bernardi R, Cappugi G, Scala A, Pazzagli L. Cerato-populin and cerato-platanin, two non-catalytic proteins from phytopathogenic fungi, interact with hydrophobic inanimate surfaces and leaves. Mol Biotechnol. 2013 Sep;55(1):27-42. doi: 10.1007/s12033-012-9618-4. PMID: 23117544. 3: Baroni F, Pazzagli L, Luti S, Scala A, Martellini F, Franzoni L, Pertinhez TA, Spisni A. ¹H, ¹⁵N, and ¹³C resonance assignment of cerato-populin, a fungal PAMP from Ceratocystis populicola. Biomol NMR Assign. 2014 Oct;8(2):405-8. doi: 10.1007/s12104-013-9527-x. Epub 2013 Oct 4. PMID: 24091893. 4: Lombardi L, Faoro F, Luti S, Baccelli I, Martellini F, Bernardi R, Picciarelli P, Scala A, Pazzagli L. Differential timing of defense-related responses induced by cerato-platanin and cerato-populin, two non-catalytic fungal elicitors. Physiol Plant. 2013 Nov;149(3):408-21. doi: 10.1111/ppl.12041. Epub 2013 Apr 2. PMID: 23438009. 5: Turóczi B, Bakonyi J, Szabó KA, Bálint J, Máthé I, Lányi S, Balog A. In Vitro and In Vivo Effect of Poplar Bud Extracts on Phytophthora infestans: A New Effective Biological Method in Potato Late Blight Control. Plants (Basel). 2020 Feb 8;9(2):217. doi: 10.3390/plants9020217. PMID: 32046312; PMCID: PMC7076697. 6: Comparini C, Carresi L, Pagni E, Sbrana F, Sebastiani F, Luchi N, Santini A, Capretti P, Tiribilli B, Pazzagli L, Cappugi G, Scala A. New proteins orthologous to cerato-platanin in various Ceratocystis species and the purification and characterization of cerato-populin from Ceratocystis populicola. Appl Microbiol Biotechnol. 2009 Aug;84(2):309-22. doi: 10.1007/s00253-009-1998-4. Epub 2009 Apr 22. PMID: 19387635. 7: Populin L, Stebbing MJ, Furness JB. Neuronal regulation of the gut immune system and neuromodulation for treating inflammatory bowel disease. FASEB Bioadv. 2021 Aug 27;3(11):953-966. doi: 10.1096/fba.2021-00070. PMID: 34761177; PMCID: PMC8565205. 8: Pobłocka-Olech L, van Nederkassel AM, Vander Heyden Y, Krauze-Baranowska M, Glód D, Baczek T. Chromatographic analysis of salicylic compounds in different species of the genus Salix. J Sep Sci. 2007 Nov;30(17):2958-66. doi: 10.1002/jssc.200700137. PMID: 17880029. 9: Veach AM, Morris R, Yip DZ, Yang ZK, Engle NL, Cregger MA, Tschaplinski TJ, Schadt CW. Rhizosphere microbiomes diverge among Populus trichocarpa plant-host genotypes and chemotypes, but it depends on soil origin. Microbiome. 2019 May 18;7(1):76. doi: 10.1186/s40168-019-0668-8. Erratum in: Microbiome. 2021 Jan 22;9(1):21. doi: 10.1186/s40168-021-01003-2. PMID: 31103040; PMCID: PMC6525979. 10: Sulima P, Krauze-Baranowska M, Przyborowski JA. Variations in the chemical composition and content of salicylic glycosides in the bark of Salix purpurea from natural locations and their significance for breeding. Fitoterapia. 2017 Apr;118:118-125. doi: 10.1016/j.fitote.2017.03.005. Epub 2017 Mar 15. PMID: 28315389. 11: Populin LC, Yin TC. Behavioral studies of sound localization in the cat. J Neurosci. 1998 Mar 15;18(6):2147-60. doi: 10.1523/JNEUROSCI.18-06-02147.1998. PMID: 9482800; PMCID: PMC6792927. 12: Rajala AZ, Jenison RL, Populin LC. Neural correlate of auditory spatial attention allocation in the superior colliculus. J Neurophysiol. 2018 Apr 1;119(4):1450-1460. doi: 10.1152/jn.00854.2017. Epub 2017 Dec 27. PMID: 29357462; PMCID: PMC5966741. 13: Guiré R, Salo P, Zongo E, Ramadan MF, Koama BK, Meda RN, Al-Asmari F, Rahim MA. The inhibitory activities of two compounds from Securidaca longepedunculata Fresen on the acetylcholinesterase from wheat pest Schizaphis graminum Rondani: in silico analysis. Plant Signal Behav. 2025 Dec;20(1):2444311. doi: 10.1080/15592324.2024.2444311. Epub 2024 Dec 19. PMID: 39701807; PMCID: PMC11660410. 14: Populin LC, Rajala AZ, Matkowskyj KA, Saha S, Zeng W, Christian B, McVea A, Tay EX, Mueller EM, Malone ME, Brust-Mascher I, McMillan AB, Ludwig KA, Suminski AJ, Reardon C, Furness JB. Characterization of idiopathic chronic diarrhea and associated intestinal inflammation and preliminary observations of effects of vagal nerve stimulation in a non-human primate. Neurogastroenterol Motil. 2024 Sep;36(9):e14876. doi: 10.1111/nmo.14876. Epub 2024 Jul 27. PMID: 39072841; PMCID: PMC11321913. 15: Baldi P, Asquini E, Nicolussi Golo G, Populin F, Moser M. Isoenzymes of the Flavonoid and Phenylpropanoid Pathways Show Organ-Specific Regulation during Apple Fruit Development. Int J Mol Sci. 2023 Sep 20;24(18):14353. doi: 10.3390/ijms241814353. PMID: 37762656; PMCID: PMC10532258. 16: Barmore AJ, Castex SM, Gouletas BA, Griffith AJ, Metz SW, Muelder NG, Populin MJ, Sackett DM, Schuster AM, Veldkamp CT. Transferring the C-terminus of the chemokine CCL21 to CCL19 confers enhanced heparin binding. Biochem Biophys Res Commun. 2016 Sep 2;477(4):602-606. doi: 10.1016/j.bbrc.2016.06.098. Epub 2016 Jun 21. PMID: 27338641; PMCID: PMC4967021. 17: Rajala AZ, Jenison RL, Populin LC. Decision making: effects of methylphenidate on temporal discounting in nonhuman primates. J Neurophysiol. 2015 Jul;114(1):70-9. doi: 10.1152/jn.00278.2015. Epub 2015 May 13. PMID: 25972584; PMCID: PMC4507955. 18: Suminski AJ, Rajala AZ, Birn RM, Mueller EM, Malone ME, Ness JP, Filla C, Brunner K, McMillan AB, Poore SO, Williams JC, Murali D, Brzeczkowski A, Hurley SA, Dingle AM, Zeng W, Lake WB, Ludwig KA, Populin LC. Vagus nerve stimulation in the non-human primate: implantation methodology, characterization of nerve anatomy, target engagement and experimental applications. Bioelectron Med. 2023 Apr 28;9(1):9. doi: 10.1186/s42234-023-00111-8. PMID: 37118841; PMCID: PMC10148417. 19: Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC. Changes in Endogenous Dopamine Induced by Methylphenidate Predict Functional Connectivity in Nonhuman Primates. J Neurosci. 2019 Feb 20;39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018. Epub 2018 Dec 10. PMID: 30530859; PMCID: PMC6381257. 20: Rajala AZ, Henriques JB, Populin LC. Dissociative effects of methylphenidate in nonhuman primates: trade-offs between cognitive and behavioral performance. J Cogn Neurosci. 2012 Jun;24(6):1371-81. doi: 10.1162/jocn_a_00225. Epub 2012 Mar 8. PMID: 22401288; PMCID: PMC3409297.

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PF3845yne

PF3845yne