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MedKoo Cat#: 146171 | Name: Nooglutyl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nooglutyl is a synthetic nootropic compound that has been studied for its potential cognitive-enhancing properties. It is thought to improve brain function by increasing the levels of certain neurotransmitters, such as acetylcholine, which are involved in memory, learning, and overall cognitive performance. Nooglutyl works by enhancing synaptic plasticity, promoting neuroprotection, and supporting the communication between neurons. It is used primarily as a cognitive enhancer and has been investigated for its potential in treating neurodegenerative diseases like Alzheimer's.

Chemical Structure

Nooglutyl
Nooglutyl
CAS#112193-35-8

Theoretical Analysis

MedKoo Cat#: 146171

Name: Nooglutyl

CAS#: 112193-35-8

Chemical Formula: C11H12N2O6

Exact Mass: 268.0695

Molecular Weight: 268.23

Elemental Analysis: C, 49.26; H, 4.51; N, 10.44; O, 35.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nooglutyl;
IUPAC/Chemical Name
(5-hydroxynicotinoyl)-L-glutamic acid
InChi Key
XFZGYOJFPGPYCS-QMMMGPOBSA-N
InChi Code
1S/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
SMILES Code
OC(=O)CC[C@H](NC(=O)C1=CN=CC(O)=C1)C(O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 268.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garibova TL, Voronina TA, Litvinova SA, Grigor'ev VV, Bachurin SO. [Effect of nooglutyl on the behavior and memory of SAMP10 mice with genetically determined accelerated aging]. Eksp Klin Farmakol. 2007 Jul-Aug;70(4):3-6. Russian. PMID: 18078032. 2: Voronina TA. Novye napravleniia poiska nootropnykh preparatov [New trends in the search for nootropic preparations]. Vestn Ross Akad Med Nauk. 1998;(11):16-21. Russian. PMID: 9889699. 3: Povarova OV, Garibova TL, Kalenikova EI, Galaeva IP, Kraĭneva VA, Medvedev OS, Voronina TA. Vliianie fenil-t-butilnitrona, meksidola i noogliutila na zonu ishemicheskogo porazheniia mozga i pamiat' krys posle okkliuzii sredneĭ mozgovoĭ arterii [Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion]. Eksp Klin Farmakol. 2004 Jan-Feb;67(1):3-6. Russian. PMID: 15079898. 4: Voronina TA. Rol' sinapticheskoĭ peredachi v protsessakh pamiati, neĭrodegeneratsii i mekhanizme deĭstviia neĭrotropnykh preparatov [The role of synaptic transmission in memory and neurodegeneration processes and effects of neurotropic preparations]. Eksp Klin Farmakol. 2003 Mar-Apr;66(2):10-4. Russian. PMID: 12962041. 5: Trofimov SS, Ostrovskaia RU, Smol'nikova NM, Nemova EP, Gudasheva TA, Kuznetsova EA, Voronina TA. Korrekstiia noogliutilom i amidom L-piroglutamil-D- alanina kognitivnykh narusheniĭ u krys, vyzvannykh vnutriutrobnoĭ gipoksieĭ [The correction with nooglutil and L-pyroglutamyl-D-alanine amide of cognitive disorders in rats due to intrauterine hypoxia]. Eksp Klin Farmakol. 1995 Nov- Dec;58(6):10-3. Russian. PMID: 8704601. 6: Iasnetsov VV, Krylova IN, Provornova NA. Farmakologicheskaia korrektsiia narusheniĭ mnesticheskikh funktsiĭ, vyzvannykh gipoksieĭ i ishemieĭ golovnogo mozga u krys [Pharmacological treatment of memory disorders caused by hypoxia and cerebral ischemia in rats]. Aviakosm Ekolog Med. 1998;32(1):55-60. Russian. PMID: 9606516. 7: Voronina TA, Garibova TL, Trofimov SS, Sopyev ZhA, Petkov VD, Lazarova MB. Comparative studies on the influence of ONK (N(5-hydroxynicotinoil) glutamic acid), piracetam and meclofenoxate on the learning- and memory-impairing effect of scopolamine, clonidine, and methergoline. Acta Physiol Pharmacol Bulg. 1991;17(4):8-16. PMID: 1841522. 8: Garibova TL, Galaeva IP, Voronina TA, Kraĭneva VA, Kapitsa IG, Kirichenko SV, Makarenko AN, Mirzoian GR, Kuznetsova EA. Effekt noogliutila u krys s intratserebral'noĭ postravmaticheskoĭ gematomoĭ (gemorragicheskim insul'tom) [Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)]. Eksp Klin Farmakol. 2003 May-Jun;66(3):13-6. Russian. PMID: 12924225. 9: Voronina TA. Gipoksiia i pamiat'. Osobennosti éffektov i primeneniia nootropnykh preparatov [Hypoxia and memory. Specific features of nootropic agents effects and their use]. Vestn Ross Akad Med Nauk. 2000;(9):27-34. Russian. PMID: 11055197. 10: Iasnetsov VV, Krylova IN. [The antiamnestic effect of nootropic substances in rats]. Eksp Klin Farmakol. 2013;76(11):3-6. Russian. PMID: 24555225. 11: Novikov VE, Kovaleva LA. Vliianie nootropov na funktsiiu mitokhondriĭ mozga v dinamike cherepno-mozgovoĭ travmy v vozrastnom aspekte [The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect]. Eksp Klin Farmakol. 1998 Mar- Apr;61(2):65-8. Russian. PMID: 9621180. 12: Trofimov SS, Ostrovskaia RU, Smol'nikova NM, Khromova IV, Krapivin SV, Krylova AM, Kovalev GI, Gaĭnetdinov RR, Liubimov BI, Voronina TA. Korrektsiia noogliutilom narusheniĭ funktsiĭ tsentral'noĭ nervnoĭ sistemy, vyzvannykh prenatal'noĭ alkogolizatsieĭ u krys [The nooglutil correction of functional disorders of the central nervous system caused by prenatal alcoholization in rats]. Eksp Klin Farmakol. 1992 Jan-Feb;55(1):18-21. Russian. PMID: 1305426. 13: Voronina TA, Borlikova GG, Garibova TL, Proskuryakova TV, Petrichenko OB, Burd SG, Avakyan GN. Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum. Bull Exp Biol Med. 2002 Nov;134(5):448-50. doi: 10.1023/a:1022634112815. PMID: 12802448. 14: Kiselev AV, Stovbun SV, Sergienko VI. [The influence of calcium N-(5-hydroxynicotinoyl)-L-glutamate on reproductive function, prenatal and postnatal development of rats]. Eksp Klin Farmakol. 2012;75(2):26-9. Russian. PMID: 22550856. 15: Voronina TA, Garibova TL, Khromova IV, Kuznetsova EA, Smirnov LD. Novoe veshchestvo s nootropnoĭ aktivnost'iu--N-5(okinikotinoil)-L-glutaminovaia kislota [A new substance with nootropic activity-- N-5(hydroxynicotinoyl)-L-glutamic acid]. Farmakol Toksikol. 1990 Jul- Aug;53(4):13-6. Russian. PMID: 1977613. 16: Firstova IuIu, Vasil'eva EV, Kovalev GI. [Studying specific effects of nootropic drugs on glutamate receptors in the rat brain]. Eksp Klin Farmakol. 2011;74(1):6-10. Russian. PMID: 21476267. 17: Firstova IuIu, Dolotov OV, Kondrakhin eA, Dubynina EV, Grivennikov IA, Kovalev GI. [Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy]. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):3-6. Russian. PMID: 20095391. 18: Vasil'eva EV, Salimov RM, Kovalev GI. [Effects of nootropic drugs on behavior of BALB/c and C57BL/6 mice in the exploratory cross-maze test]. Eksp Klin Farmakol. 2012;75(7):3-7. Russian. PMID: 23025044. 19: Motin V, Yasnetsov V, Kovalev S, Krylova I. Effects of nootropics on electrical activity in rat hippocampal CA1 area. Bull Exp Biol Med. 2000 Sep;130(9):830-1. PMID: 11177255. 20: Firsov AA, Portnoĭ IuA, Dovzhenko SA, Kobrin MB, Kiselev AV, Stovbun SV, Dolgova GV, Pomerantseva TIa. [Pharmacokinetics of n-(5-oxynicotinoyl)-L-glutamic acid calcium salt upon bolus administration in rats and rabbits: interspecies extrapolation]. Eksp Klin Farmakol. 2010 Dec;73(12):31-5. Russian. PMID: 21395015.