Isoacteoside | CAS#61303-13-7 | biochemical

MedKoo Cat#: 146163 | Name: Isoacteoside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoacteoside is a naturally occurring phenylethanoid glycoside found in several plants, including Actea and Veronica species. It exhibits insecticidal and antimicrobial properties, working by disrupting the metabolic and physiological processes of pests. The mechanism of action involves the inhibition of key enzymes and interfering with the cellular functions of insects, leading to growth disruption and death. Isoacteoside is used in agricultural practices as a natural pesticide to control a variety of insect pests, providing a safer and environmentally friendly alternative to synthetic chemicals.

Chemical Structure

Isoacteoside

CAS#61303-13-7

Theoretical Analysis

MedKoo Cat#: 146163

Name: Isoacteoside

CAS#: 61303-13-7

Chemical Formula: C29H36O15

Exact Mass: 624.2054

Molecular Weight: 624.59

Elemental Analysis: C, 55.77; H, 5.81; O, 38.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Isoacteoside; Isoverbascoside;

IUPAC/Chemical Name

((2R,3R,4S,5R,6R)-6-(3,4-dihydroxyphenethoxy)-3,5-dihydroxy-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl (E)-3-(3,4-dihydroxyphenyl)acrylate

InChi Key

FNMHEHXNBNCPCI-QEOJJFGVSA-N

InChi Code

1S/C29H36O15/c1-13-22(35)24(37)25(38)29(42-13)44-27-23(36)20(12-41-21(34)7-4-14-2-5-16(30)18(32)10-14)43-28(26(27)39)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27-,28+,29-/m0/s1

SMILES Code

C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](COC(=O)\C=C\C3=CC=C(O)C(O)=C3)O[C@@H](OCCC4=CC=C(O)C(O)=C4)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 624.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang B, Li XH, Song Z, Li ML, Wu XW, Guo MX, Zhang XH, Zou XP. Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis. Mol Med Rep. 2021 Apr;23(4):287. doi: 10.3892/mmr.2021.11926. Epub 2021 Mar 2. PMID: 33649800. 2: Zhao L, Qi H, Liu W, Lv H, Li P, Liu W, Sun R, Wang Q, Wang X. Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism. Commun Biol. 2025 Feb 8;8(1):205. doi: 10.1038/s42003-025-07622-x. PMID: 39922943; PMCID: PMC11807089. 3: Gao H, Cui Y, Kang N, Liu X, Liu Y, Zou Y, Zhang Z, Li X, Yang S, Li J, Wang C, Xu QM, Chen X. Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti- inflammatory effects through blocking toll-like receptor 4 dimerization. Br J Pharmacol. 2017 Sep;174(17):2880-2896. doi: 10.1111/bph.13912. Epub 2017 Jul 14. PMID: 28616865; PMCID: PMC5554315. 4: Nam SY, Kim HY, Yoou MS, Kim AH, Park BJ, Jeong HJ, Kim HM. Anti-inflammatory effects of isoacteoside from Abeliophyllum distichum. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):258-64. doi: 10.3109/08923973.2015.1026604. Epub 2015 May 15. PMID: 25975581. 5: Shiao YJ, Su MH, Lin HC, Wu CR. Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 24;18(4):895. doi: 10.3390/ijms18040895. PMID: 28441758; PMCID: PMC5412474. 6: Lian J, Xu Y, Shi J, Liu P, Hua Y, Zhang C, Ren T, Su G, Cheng S, Nie Z, Jia T. Acteoside and isoacteoside alleviate renal dysfunction and inflammation in lipopolysaccharide-induced acute kidney injuries through inhibition of NF-κB signaling pathway. PLoS One. 2024 May 15;19(5):e0303740. doi: 10.1371/journal.pone.0303740. PMID: 38748639; PMCID: PMC11095724. 7: Chae S, Kim JS, Kang KA, Bu HD, Lee Y, Seo YR, Hyun JW, Kang SS. Antioxidant activity of isoacteoside from Clerodendron trichotomum. J Toxicol Environ Health A. 2005 Mar 12;68(5):389-400. doi: 10.1080/15287390590900750. PMID: 15799629. 8: Yang X, Guo F, Peng Q, Liu Y, Yang B. Suppression of in vitro and in vivo human ovarian cancer growth by isoacteoside is mediated via sub-G1 cell cycle arrest, ROS generation, and modulation of AKT/PI3K/m-TOR signalling pathway. J BUON. 2019 Jan-Feb;24(1):285-290. PMID: 30941982. 9: Pettit GR, Numata A, Takemura T, Ode RH, Narula AS, Schmidt JM, Cragg GM, Pase CP. Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia. J Nat Prod. 1990 Mar-Apr;53(2):456-8. doi: 10.1021/np50068a026. PMID: 2380718. 10: Liu YH, Lu YL, Han CH, Hou WC. Inhibitory activities of acteoside, isoacteoside, and its structural constituents against protein glycation in vitro. Bot Stud. 2013 Dec;54(1):6. doi: 10.1186/1999-3110-54-6. Epub 2013 Aug 19. PMID: 28510849; PMCID: PMC5432847. 11: Zhou J, Zhang Q, Sun JB, Sun XL, Zeng P. Two-phase hollow fiber liquid phase microextraction based on magnetofluid for simultaneous determination of Echinacoside, Tubuloside B, Acteoside and Isoacteoside in rat plasma after oral administration of Cistanche salsa extract by high performance liquid chromatography. J Pharm Biomed Anal. 2014 Jun;94:30-5. doi: 10.1016/j.jpba.2014.01.013. Epub 2014 Jan 25. PMID: 24531006. 12: Feng B, Song Y, Xu Q, Xu P, Zeng Q, Shan B, Liu K, Su D. Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC- MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration. J Sep Sci. 2018 Dec;41(24):4408-4418. doi: 10.1002/jssc.201800545. Epub 2018 Nov 2. PMID: 30307101. 13: Li L, Tsao R, Liu Z, Liu S, Yang R, Young JC, Zhu H, Deng Z, Xie M, Fu Z. Isolation and purification of acteoside and isoacteoside from Plantago psyllium L. by high-speed counter-current chromatography. J Chromatogr A. 2005 Jan 21;1063(1-2):161-9. doi: 10.1016/j.chroma.2004.11.024. PMID: 15700468. 14: Cui Q, Pan Y, Yan X, Qu B, Liu X, Xiao W. A metabolic way to investigate related hurdles causing poor bioavailability in oral delivery of isoacteoside in rats employing ultrahigh-performance liquid chromatography/quadrupole time-of- flight tandem mass spectrometry. Rapid Commun Mass Spectrom. 2017 Feb 28;31(4):371-380. doi: 10.1002/rcm.7795. PMID: 27859774. 15: Lu Y, Zhou W, Feng Y, Li Y, Liu K, Liu L, Lin D, He Z, Wu X. Acteoside and Acyl-Migrated Acteoside, Compounds in Chinese Kudingcha Tea, Inhibit α-Amylase In Vitro. J Med Food. 2017 Jun;20(6):577-585. doi: 10.1089/jmf.2016.3910. Epub 2017 May 9. PMID: 28486011. 16: Liu M, Tan H, Xie H. Phenylethanoid glycosides from Michelia champaca leaves. Phytochemistry. 2024 Oct;226:114118. doi: 10.1016/j.phytochem.2024.114118. Epub 2024 Apr 29. PMID: 38692344. 17: Jiang T, Zhu X, Yin Z, Gao R, Li Y, Li C, Meng Q, Zhu X, Song W, Su X. Dual role of Baimao-Longdan-Congrong-Fang in inhibiting Staphylococcus aureus virulence factors and regulating TNF-α/TNFR1/NF-κB/MMP9 axis. Phytomedicine. 2025 Apr;139:156477. doi: 10.1016/j.phymed.2025.156477. Epub 2025 Feb 7. PMID: 39938176. 18: Şimşek S, Akşit H, Aydın A, Köksal E. Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum. Chem Biodivers. 2023 Dec;20(12):e202301200. doi: 10.1002/cbdv.202301200. Epub 2023 Nov 15. PMID: 37909246. 19: Fu Z, Fan X, Wang X, Gao X. Cistanches Herba: An overview of its chemistry, pharmacology, and pharmacokinetics property. J Ethnopharmacol. 2018 Jun 12;219:233-247. doi: 10.1016/j.jep.2017.10.015. Epub 2017 Oct 17. PMID: 29054705. 20: Thu VK, Thoa NT, Hien NTT, Hang DTT, Kiem PV. Iridoid glycosides link with phenylpropanoids from Rehmannia glutinosa. Nat Prod Res. 2022 Oct;36(20):5370-5375. doi: 10.1080/14786419.2021.1931189. Epub 2021 May 27. PMID: 34039230.