Synonym
Substance P (1-7) trifluoroacetate salt; Substance P (1-7); Substance P; Arg-Pro-Lys-Pro-Gln-Gln-Phe; SP (1-7)
IUPAC/Chemical Name
L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanine--2,2,2-trifluoroacetic acid (1/1)
InChi Key
NGJNGAVSGJSPNQ-OSSAIMHMSA-N
InChi Code
InChI=1S/C41H65N13O10.C2HF3O2/c42-19-5-4-12-28(51-37(60)30-13-7-21-53(30)38(61)25(43)11-6-20-48-41(46)47)39(62)54-22-8-14-31(54)36(59)50-27(16-18-33(45)56)34(57)49-26(15-17-32(44)55)35(58)52-29(40(63)64)23-24-9-2-1-3-10-24;3-2(4,5)1(6)7/h1-3,9-10,25-31H,4-8,11-23,42-43H2,(H2,44,55)(H2,45,56)(H,49,57)(H,50,59)(H,51,60)(H,52,58)(H,63,64)(H4,46,47,48);(H,6,7)/t25-,26-,27-,28-,29-,30-,31-;/m0./s1
SMILES Code
O=C([C@H]1N(C([C@@H](NC([C@H]2N(C([C@@H](N)CCCNC(N)=N)=O)CCC2)=O)CCCCN)=O)CCC1)N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)=O.OC(C(F)(F)F)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,014.08
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Hall, M.E., Miley, F., and Stewart, J.M. The role of enzymatic processing in the biological actions of substance P. Peptides 10(4), 895-901 (1989).
2. Michael-Titus, A.T., Blackburn, D., Connolly, Y., et al. N- and C-terminal substance P fragments: Differential effects on striatal [3H]substance P binding and NK1 receptor internalization. Neuroreport 13(10), 2209-2213 (1999).
3. Herrera-Marschitz, M., Terenius, L., Sakurada, T., et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 521(1-2), 316-320 (1990).
4. Kreeger, J.S., and Larson, A.A. Substance P-(1-7), a substance P metabolite, inhibits withdrawal jumping in morphine-dependent mice. Eur. J. Pharmacol. 238(1), 111-115 (1993).
5. Carlsson, A., Ohsawa, M., Hallberg, M., et al. Substance P(1-7) induces antihyperalgesia in diabetic mice through a mechanism involving the naloxone-sensitive sigma receptors. Eur. J. Pharmacol. 626(2-3), 250-255 (2010).
6. De Araújo, J.E., Huston, J.P., and Brandão, M.L. Opposite effects of substance P fragments C (anxiogenic) and N (anxiolytic) injected into dorsal periaqueductal gray. Eur. J. Pharmacol. 432(1), 43-51 (2001).
