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MedKoo Cat#: 146143 | Name: Alaptide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alaptide is a synthetic antimicrobial peptide that has shown effectiveness in targeting and inhibiting the growth of various pathogenic bacteria and fungi. It is primarily used in the development of novel therapeutic agents for treating infections, particularly those caused by antibiotic-resistant microorganisms. Alaptide works by disrupting the integrity of microbial cell membranes, forming pores that lead to leakage of essential cellular components, ultimately causing cell death.

Chemical Structure

Alaptide
Alaptide
CAS#90058-29-0

Theoretical Analysis

MedKoo Cat#: 146143

Name: Alaptide

CAS#: 90058-29-0

Chemical Formula: C9H14N2O2

Exact Mass: 182.1055

Molecular Weight: 182.22

Elemental Analysis: C, 59.32; H, 7.74; N, 15.37; O, 17.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Alaptide;
IUPAC/Chemical Name
(S)-8-methyl-6,9-diazaspiro[4.5]decane-7,10-dione
InChi Key
LTRSPDHUDXWHRY-LURJTMIESA-N
InChi Code
1S/C9H14N2O2/c1-6-7(12)11-9(8(13)10-6)4-2-3-5-9/h6H,2-5H2,1H3,(H,10,13)(H,11,12)/t6-/m0/s1
SMILES Code
C[C@@H]1NC(=O)C2(CCCC2)NC1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mikeš P, Brož A, Sinica A, Asatiani N, Bačáková L. In vitro and in vivo testing of nanofibrous membranes doped with alaptide and L-arginine for wound treatment. Biomed Mater. 2020 Nov 26;15(6):065023. doi: 10.1088/1748-605X/ab950f. Erratum in: Biomed Mater. 2023 Oct 03;18(6). doi: 10.1088/1748-605X/acfad9. PMID: 32434166. 2: Mikeš P, Brož A, Sinica A, Asatiani N, Bačáková L. Corrigendum:In vitroandin vivotesting of nanofibrous membranes doped with alaptide and L-arginine for wound treatment (2020Biomed. Mater.15065023). Biomed Mater. 2023 Oct 3;18(6). doi: 10.1088/1748-605X/acfad9. Erratum for: Biomed Mater. 2020 Nov 26;15(6):065023. doi: 10.1088/1748-605X/ab950f. PMID: 37787639. 3: Julínek O, Setnicka V, Rezácová A, Dohnal J, Vosátka V, Urbanová M. Product of alaptide synthesis: determination of the absolute configuration. J Pharm Biomed Anal. 2010 Dec 1;53(4):958-61. doi: 10.1016/j.jpba.2010.07.007. Epub 2010 Aug 1. PMID: 20675091. 4: Opatrilova R, Cernikova A, Coufalova L, Dohnal J, Jampilek J. In vitro permeation of micronized and nanonized alaptide from semisolid formulations. ScientificWorldJournal. 2013 Dec 18;2013:787283. doi: 10.1155/2013/787283. PMID: 24453907; PMCID: PMC3881672. 5: Nedvídková J, Kasafírek E, Nedvídek J, Pacák K, Schreiber V. An analog of MIF, alaptide: effect on serum prolactin, dopamine receptors and growth of rat adenohypophysis. Endocr Res. 1994 Feb;20(1):39-46. doi: 10.3109/07435809409035854. PMID: 8168462. 6: Hlinak Z, Krejci I, Hynie S, Klenerova V. Dipeptide "alaptide" prevented impairments in spontaneous behavior produced with trimethyltin in male rats. Neuro Endocrinol Lett. 2008 Dec;29(6):917-23. PMID: 19112412. 7: Rohlíček J, Maixner J, Pažout R, Hušák M, Cibulková J, Kratochvíl B. Alaptide from synchrotron powder diffraction data. Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 13;66(Pt 4):o821. doi: 10.1107/S1600536810007750. PMID: 21580652; PMCID: PMC2983785. 8: Hlinák Z, Vinsová J, Kasafírek E. Effect of alaptide, its analogues and oxiracetam on memory for an elevated plus-maze in mice. Eur J Pharmacol. 1996 Oct 24;314(1-2):1-7. doi: 10.1016/s0014-2999(96)00485-2. PMID: 8957212. 9: Hlinák Z, Krejcí I. Modulation of social memory in rats by alaptide, a derivative of MIF. Homeost Health Dis. 1991;33(5-6):262-73. PMID: 18265492. 10: Douša M, Lemr K. Liquid chromatographic method for enantiopurity control of alaptide using polysaccharide stationary phases. J Sep Sci. 2011 Jun;34(12):1402-6. doi: 10.1002/jssc.201100135. Epub 2011 May 5. PMID: 21548088. 11: Lapka R. Pharmacokinetics and brain entry of alaptide, a novel nootropic agent, in mice, rats and rabbits. J Pharm Pharmacol. 1991 Dec;43(12):874-6. doi: 10.1111/j.2042-7158.1991.tb03200.x. PMID: 1687590. 12: Pokorna A, Bobal P, Oravec M, Rarova L, Bobalova J, Jampilek J. Investigation of Permeation of Theophylline through Skin Using Selected Piperazine-2,5-Diones. Molecules. 2019 Feb 4;24(3):566. doi: 10.3390/molecules24030566. PMID: 30720734; PMCID: PMC6385378. 13: Keilhoff G, Wolf G, Stastný F. Effects of MK-801, ketamine and alaptide on quinolinate models in the maturing hippocampus. Neuroscience. 1991;42(2):379-85. doi: 10.1016/0306-4522(91)90382-x. PMID: 1832751. 14: Lebedev AA, Panchenko GN, Shabanov PD. Deĭstvie analoga melanostatina alaptida na dofaminozavisimye formy povedeniia u krys, vyrashchennykh v izoliatsii [Effect of the melanostatin analogue alaptide on dopamine-dependent behavior in rats reared in isolation]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2000 Jul-Aug;50(4):716-9. Russian. PMID: 10984916. 15: Hlinák Z, Krejcí I. Social recognition in male rats: age differences and modulation by MIF-I and Alaptide. Physiol Res. 1991;40(1):59-67. PMID: 1681894. 16: Hlinák Z, Krejcí I, Hondlík J, Yamamoto A. Behavioral consequences of sodium nitrite hypoxia in male rats: amelioration with alaptide treatment. Methods Find Exp Clin Pharmacol. 1990 Jul-Aug;12(6):385-93. PMID: 2090122. 17: Vitková Z, Smunková V, Herdová P, Zabka M. Vplyv membrán na permeáciu alaptidu z hydrogélov [Influence of membranes on alaptide permeation from hydrogels]. Ceska Slov Farm. 2011 Jun;60(3):132-6. Slovak. PMID: 21838143. 18: Hlinák Z, Krejcí I. Prolonged social recognition in male rats treated with alaptide or oxiracetam. Behav Pharmacol. 1992 Apr;3(2):129-131. PMID: 11224110. 19: Lebedev AA, Shabanov PD, Chepurnova NE, Paskhali E, Krejcí I, Kasafírek E. Lateralizovannye éffekty analoga melanostatina alaptida u krys, vyrashchennykh v izoliatsii i soobshchestve [The lateralized effects of the melanostatin analog alaptide in rats raised in isolation and in a community]. Fiziol Zh Im I M Sechenova. 1994 Oct;80(10):24-31. Russian. PMID: 7536538. 20: Dlohozková N, Krejcí I, Hlinák Z, Schuh J, Valchár M. Biochemical and behavioral effects of alaptide, a spirocyclic dipeptide derived from Pro-Leu- Gly-NH2. Act Nerv Super (Praha). 1989 Apr;31(1):79-80. PMID: 2782014.