MedKoo Cat#: 128698 | Name: PSB-12062

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-12062 is a P2X4 Antagonist.

Chemical Structure

PSB-12062
PSB-12062
CAS#55476-47-6

Theoretical Analysis

MedKoo Cat#: 128698

Name: PSB-12062

CAS#: 55476-47-6

Chemical Formula: C19H15NO3S

Exact Mass: 337.0773

Molecular Weight: 337.39

Elemental Analysis: C, 67.64; H, 4.48; N, 4.15; O, 14.23; S, 9.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PSB-12062; PSB12062; PSB 12062; N-(p-Methylphenylsulfonyl)phenoxazine
IUPAC/Chemical Name
10-tosyl-10H-phenoxazine
InChi Key
DHZNMEIBMACSFH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3
SMILES Code
O=S(N1C2=C(C=CC=C2)OC3=CC=CC=C13)(C4=CC=C(C)C=C4)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 337.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Imraish A, Abu-Thiab T, Hammad H. P2X and P2Y receptor antagonists reduce inflammation in ATP-induced microglia. Pharm Pract (Granada). 2023 Jan- Mar;21(1):2788. doi: 10.18549/PharmPract.2023.1.2788. Epub 2022 Jan 5. PMID: 37090457; PMCID: PMC10117305. 2: Stokes L, Layhadi JA, Bibic L, Dhuna K, Fountain SJ. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology. Front Pharmacol. 2017 May 23;8:291. doi: 10.3389/fphar.2017.00291. PMID: 28588493; PMCID: PMC5441391. 3: Orriss IR, Davies BK, Bourne LE, Arnett TR. Modulation of osteoblast differentiation and function by the P2X4 receptor. Purinergic Signal. 2023 Jun;19(2):367-378. doi: 10.1007/s11302-022-09887-x. Epub 2022 Aug 17. PMID: 35976527; PMCID: PMC10247667. 4: Fortuny-Gomez A, Fountain SJ. Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools. Purinergic Signal. 2024 Dec;20(6):659-667. doi: 10.1007/s11302-024-10018-x. Epub 2024 May 20. PMID: 38767821; PMCID: PMC11554605. 5: Hernandez-Olmos V, Abdelrahman A, El-Tayeb A, Freudendahl D, Weinhausen S, Müller CE. N-substituted phenoxazine and acridone derivatives: structure- activity relationships of potent P2X4 receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9576-88. doi: 10.1021/jm300845v. Epub 2012 Nov 1. PMID: 23075067. 6: Xiang Z, Jiang X, Ji R, Yuan H. Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia- reperfusion injury. Purinergic Signal. 2021 Sep;17(3):425-438. doi: 10.1007/s11302-021-09780-z. Epub 2021 May 9. PMID: 33966147; PMCID: PMC8410916. 7: Layhadi JA, Fountain SJ. P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages. Int J Mol Sci. 2017 Oct 27;18(11):2261. doi: 10.3390/ijms18112261. PMID: 29077063; PMCID: PMC5713231. 8: Layhadi JA, Turner J, Crossman D, Fountain SJ. ATP Evokes Ca2+ Responses and CXCL5 Secretion via P2X4 Receptor Activation in Human Monocyte-Derived Macrophages. J Immunol. 2018 Feb 1;200(3):1159-1168. doi: 10.4049/jimmunol.1700965. Epub 2017 Dec 18. PMID: 29255078; PMCID: PMC5784824. 9: Wildner F, Neuhäusel TS, Klemz A, Kovács R, Ulmann L, Geiger JRP, Gerevich Z. Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors. Br J Pharmacol. 2024 Jun;181(11):1635-1653. doi: 10.1111/bph.16298. Epub 2024 Jan 31. PMID: 38073073. 10: He J, Zhou Y, Arredondo Carrera HM, Sprules A, Neagu R, Zarkesh SA, Eaton C, Luo J, Gartland A, Wang N. Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target. Cells. 2020 Nov 20;9(11):2511. doi: 10.3390/cells9112511. PMID: 33233569; PMCID: PMC7699771.