MedKoo Cat#: 128693 | Name: hCAII Degrader 11
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

hCAII Degrader 11 is a potent human carbonic anhydrase II (hCAII) Degrader (PROTAC®; Dmax = 100% at 5 nM, DC50 = 0.5 nM).

Chemical Structure

hCAII Degrader 11
hCAII Degrader 11
CAS#2892306-56-6

Theoretical Analysis

MedKoo Cat#: 128693

Name: hCAII Degrader 11

CAS#: 2892306-56-6

Chemical Formula: C32H41N5O7S

Exact Mass: 639.2727

Molecular Weight: 639.77

Elemental Analysis: C, 60.08; H, 6.46; N, 10.95; O, 17.51; S, 5.01

Price and Availability

Size Price Availability Quantity
2mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
hCAII Degrader 11; hCAII Degrader-11; hCAII-Degrader 11; hCAII-Degrader-11
IUPAC/Chemical Name
N-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)dodecyl)-4-sulfamoylbenzamide
InChi Key
AZBRPAQQOMDJLZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H41N5O7S/c33-45(43,44)23-16-14-22(15-17-23)29(39)35-21-10-8-6-4-2-1-3-5-7-9-20-34-25-13-11-12-24-28(25)32(42)37(31(24)41)26-18-19-27(38)36-30(26)40/h11-17,26,34H,1-10,18-21H2,(H,35,39)(H2,33,43,44)(H,36,38,40)
SMILES Code
O=C(NCCCCCCCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(S(=O)(N)=O)C=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 639.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
O'Herin CB, Moriuchi YW, Bemis TA, Kohlbrand AJ, Burkart MD, Cohen SM. Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J Med Chem. 2023 Feb 23;66(4):2789-2803. doi: 10.1021/acs.jmedchem.2c01843. Epub 2023 Feb 3. PMID: 36735827; PMCID: PMC9969396.