KL 465 | MAGE-A3 Degrader | CAS#3057446-82-6

MedKoo Cat#: 128692 | Name: KL 465

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KL 465 is a MAGE-A3 Degrader (PROTAC®) (DC50 = 2 μM; Dmax = 60%).

Chemical Structure

KL 465

CAS#3057446-82-6

Theoretical Analysis

MedKoo Cat#: 128692

Name: KL 465

CAS#: 3057446-82-6

Chemical Formula: C56H60N8O9S

Exact Mass: 1020.4204

Molecular Weight: 1021.20

Elemental Analysis: C, 65.87; H, 5.92; N, 10.97; O, 14.10; S, 3.14

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 750.00	2 Weeks

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Related CAS #

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Synonym

KL 465; KL465; KL-465

IUPAC/Chemical Name

(2S,4R)-N-(2-(2-(2-(2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-4-(1H-indazol-4-yl)phenoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide

InChi Key

MQOTXOOWIOCPNH-IYCLWVRSSA-N

InChi Code

InChI=1S/C56H60N8O9S/c1-35(2)51(64-32-40-8-4-5-9-44(40)54(64)67)56(69)63-33-42(65)28-47(63)53(66)57-29-39-14-13-38(52-36(3)58-34-74-52)27-50(39)73-25-23-70-22-24-72-48-16-15-37(43-10-6-11-46-45(43)30-59-60-46)26-41(48)31-61-17-19-62(20-18-61)55(68)49-12-7-21-71-49/h4-16,21,26-27,30,34-35,42,47,51,65H,17-20,22-25,28-29,31-33H2,1-3H3,(H,57,66)(H,59,60)/t42-,47+,51+/m1/s1

SMILES Code

O=C(C1=CC=CO1)N2CCN(CC2)CC3=CC(C4=CC=CC5=C4C=NN5)=CC=C3OCCOCCOC6=CC(C7=C(N=CS7)C)=CC=C6CNC([C@@H]8C[C@H](CN8C([C@H](C(C)C)N9CC%10=C(C9=O)C=CC=C%10)=O)O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,021.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Li K, Krone MW, Butrin A, Bond MJ, Linhares BM, Crews CM. Development of Ligands and Degraders Targeting MAGE-A3. J Am Chem Soc. 2024 Sep 11;146(36):24884-24891. doi: 10.1021/jacs.4c05393. Epub 2024 Aug 27. PMID: 39190582.