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MedKoo Cat#: 146109 | Name: Phenetrazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenetrazine is a chemical compound classified as a monoamine oxidase inhibitor (MAOI), often used in the treatment of depression and anxiety disorders. It works by inhibiting the activity of the enzyme monoamine oxidase, which is responsible for breaking down neurotransmitters like serotonin, dopamine, and norepinephrine, thus increasing their levels in the brain and improving mood. Beyond psychiatry, phenetrazine has also been explored in the context of enhancing cognitive function and as a potential performance-enhancing agent.

Chemical Structure

Phenetrazine
Phenetrazine
CAS#100368-98-7

Theoretical Analysis

MedKoo Cat#: 146109

Name: Phenetrazine

CAS#: 100368-98-7

Chemical Formula: C12H17NO

Exact Mass: 191.1310

Molecular Weight: 191.27

Elemental Analysis: C, 75.35; H, 8.96; N, 7.32; O, 8.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Phenetrazine;
IUPAC/Chemical Name
3-ethyl-2-phenylmorpholine
InChi Key
DOMAVIHZFHQQHF-UHFFFAOYSA-N
InChi Code
1S/C12H17NO/c1-2-11-12(14-9-8-13-11)10-6-4-3-5-7-10/h3-7,11-13H,2,8-9H2,1H3
SMILES Code
CCC1NCCOC1C2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 191.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nemetz PS. Phenmetrazine psychosis. Br Med J. 1968 Sep 28;3(5621):803-4. doi: 10.1136/bmj.3.5621.803-e. PMID: 5676721; PMCID: PMC1989521. 2: Jaroszyński J, Spasowicz E, Ulasińska-Rubach D. Phenmetrazine psychoses. Pol Med J. 1971;10(1):253-7. PMID: 5573909. 3: Jiang Y, Murnane KS, Bhattaccharjee SA, Blough BE, Banga AK. Skin Delivery and Irritation Potential of Phenmetrazine as a Candidate Transdermal Formulation for Repurposed Indications. AAPS J. 2019 May 31;21(4):70. doi: 10.1208/s12248-019-0335-9. PMID: 31152318. 4: Coupar IM, Hedges A, Metcalfe HL. Fenfluramine and phenmetrazine. Lancet. 1969 Sep 13;2(7620):601. doi: 10.1016/s0140-6736(69)90312-2. PMID: 4185569. 5: MOSS PD. Phenmetrazine and foetal abnormalities. Br Med J. 1962 Dec 15;2(5319):1610. doi: 10.1136/bmj.2.5319.1610-b. PMID: 13936212; PMCID: PMC1926844. 6: Mayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Blough BE, Brandt SD, Baumann MH, Sitte HH. Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family. Neuropharmacology. 2018 May 15;134(Pt A):149-157. doi: 10.1016/j.neuropharm.2017.10.006. Epub 2017 Oct 6. PMID: 28988906; PMCID: PMC7294773. 7: PHENMETRAZINE hydrochloride. J Am Med Assoc. 1957 Feb 2;163(5):357. PMID: 13385162. 8: Lange KW. Narkolepsie [Narcolepsy]. Dtsch Med Wochenschr. 1990 Aug 17;115(33):1244-50. German. doi: 10.1055/s-2008-1065149. PMID: 2201510. 9: Negulici E, Christodorescu D. Phenmetrazine psychosis. Br Med J. 1968 Aug 3;3(5613):316. doi: 10.1136/bmj.3.5613.316-a. PMID: 5661675; PMCID: PMC1986250. 10: HAMPSON J, LORAINE JA, STRONG JA. Phenmetrazine and dexamphetamine in the management of obesity. Lancet. 1960 Jun 11;1(7137):1265-7. doi: 10.1016/s0140-6736(60)92250-9. PMID: 14399386. 11: Czoty PW, Tran P, Thomas LN, Martin TJ, Grigg A, Blough BE, Beveridge TJ. Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self- administration and cocaine-primed reinstatement in rats. Psychopharmacology (Berl). 2015 Jul;232(13):2405-14. doi: 10.1007/s00213-015-3875-4. Epub 2015 Feb 13. PMID: 25673020; PMCID: PMC4465864. 12: Jaroszyński J, Spasowicz E, Ulasińska-Rubach D. Psychozy fenmetrazynowe [Phenmetrazine psychoses]. Psychiatr Pol. 1970 Mar-Apr;4(2):151-5. Polish. PMID: 5427758. 13: Banks ML, Blough BE, Fennell TR, Snyder RW, Negus SS. Role of phenmetrazine as an active metabolite of phendimetrazine: evidence from studies of drug discrimination and pharmacokinetics in rhesus monkeys. Drug Alcohol Depend. 2013 Jun 1;130(1-3):158-66. doi: 10.1016/j.drugalcdep.2012.10.026. Epub 2012 Dec 1. PMID: 23211394; PMCID: PMC3616150. 14: Bauer CT, Negus SS, Blough BE, Banks ML. Cocaine-like discriminative stimulus effects of phendimetrazine and phenmetrazine in rats. Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):192-5. doi: 10.1097/FBP.0000000000000225. PMID: 26866973; PMCID: PMC4779707. 15: BRIGGS JH, NEWLAND PM, BISHOP PM. Phenmetrazine hydrochloride in treatment of obesity. Br Med J. 1960 Sep 24;2(5203):911-2. doi: 10.1136/bmj.2.5203.911. PMID: 13804418; PMCID: PMC2098162. 16: Wille SM, Lambert WE. Phenmetrazine or ephedrine? Fooled by library search. J Chromatogr A. 2004 Aug 6;1045(1-2):259-62. doi: 10.1016/j.chroma.2004.06.025. PMID: 15378904. 17: FELDMAN R, ALBERTON EC, CRAIG L. Phenmetrazine hydrochloride; a clinical evaluation of a new anoretic agent. Calif Med. 1957 Dec;87(6):408-10. PMID: 13489501; PMCID: PMC1512205. 18: MARTEL A. Preludin (phenmetrazine) in the treatment of obesity. Can Med Assoc J. 1957 Jan 15;76(2):117-20. PMID: 13383418; PMCID: PMC1823494. 19: OSWALD I, THACORE VR. AMPHETAMINE AND PHENMETRAZINE ADDICTION. PHYSIOLOGICAL ABNORMALITIES IN THE ABSTINENCE SYNDROME. Br Med J. 1963 Aug 17;2(5354):427-31. doi: 10.1136/bmj.2.5354.427. PMID: 14159321; PMCID: PMC1872556. 20: Drugs for depression. Br Med J. 1968 Mar 23;1(5594):753-4. PMID: 5641446; PMCID: PMC1985465.

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AHL196

AHL196