MedKoo Cat#: 146102 | Name: Pregomisin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pregomisin is a synthetic pharmaceutical compound used primarily for its effects on the central nervous system, particularly for managing symptoms associated with mood disorders, such as anxiety and depression. It functions by modulating neurotransmitter activity, often involving serotonin and norepinephrine systems, to enhance mood regulation and alleviate stress. Pregomisin is also utilized in certain clinical settings to address sleep disturbances, as it promotes relaxation and stabilizes sleep patterns.

Chemical Structure

Pregomisin
CAS#66280-26-0

Theoretical Analysis

MedKoo Cat#: 146102

Name: Pregomisin

CAS#: 66280-26-0

Chemical Formula: C22H30O6

Exact Mass: 390.2042

Molecular Weight: 390.48

Elemental Analysis: C, 67.67; H, 7.74; O, 24.58

Price and Availability

Size Price Availability Quantity
10mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Pregomisin; Pre-Gomisin;
IUPAC/Chemical Name
5,5'-((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(2,3-dimethoxyphenol)
InChi Key
RLRKIWSBYUZHIJ-OKILXGFUSA-N
InChi Code
1S/C22H30O6/c1-13(7-15-9-17(23)21(27-5)19(11-15)25-3)14(2)8-16-10-18(24)22(28-6)20(12-16)26-4/h9-14,23-24H,7-8H2,1-6H3/t13-,14+
SMILES Code
COC1=C(OC)C(O)=CC(C[C@H](C)[C@H](C)CC2=CC(OC)=C(OC)C(O)=C2)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 390.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lei C, Huang SX, Chen JJ, Pu JX, Yang LB, Zhao Y, Liu JP, Gao XM, Xiao WL, Sun HD. Lignans from Schisandra propinqua var. propinqua. Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1281-3. doi: 10.1248/cpb.55.1281. PMID: 17666862. 2: Lee IS, Jung KY, Oh SR, Kim DS, Kim JH, Lee JJ, Lee HK, Lee SH, Kim EH, Cheong C. Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis. Arch Pharm Res. 1997 Dec;20(6):633-6. doi: 10.1007/BF02975223. PMID: 18982271. 3: Hien TTT, Thang HD, Tuan HA, Tai PT, Tung NM, Van Khoi N, Hien NTT, Tram LH, Van Kiem P, Nhiem NX, Tai BH, Kim J, Choi J, Kim SH. Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation. J Nat Med. 2023 Sep;77(4):928-938. doi: 10.1007/s11418-023-01712-y. Epub 2023 Jun 9. PMID: 37294499. 4: Li B, Qiao L, Xiao Q, Zhang J, Liu J, Zhang B, Liu H. Effects of diarylbutane lignans from Schisandra chinensis fruit on SARS-CoV-2 3CLpro and PLpro and their in vitro anti-inflammatory properties. Phytomed Plus. 2023 May;3(2):100432. doi: 10.1016/j.phyplu.2023.100432. Epub 2023 Mar 11. PMID: 36968623; PMCID: PMC10005971. 5: Lin L, Tang Z, Xie H, Yang L, Yang B, Li H. Characterization of Differences in Chemical Profiles and Antioxidant Activities of Schisandra chinensis and Schisandra sphenanthera Based on Multi-Technique Data Fusion. Molecules. 2024 Oct 14;29(20):4865. doi: 10.3390/molecules29204865. PMID: 39459232; PMCID: PMC11510710. 6: Xu XM, Li L, Chen M. [Studies on the chemical constituents of Schisandra pubescens]. Zhong Yao Cai. 2009 Sep;32(9):1399-401. Chinese. PMID: 20034217.