MedKoo Cat#: 128660 | Name: TU-2218

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TU-2218 is a ALK5 inhibitor.

Chemical Structure

TU-2218
TU-2218
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128660

Name: TU-2218

CAS#: N/A

Chemical Formula: C17H15N7

Exact Mass: 317.1389

Molecular Weight: 317.36

Elemental Analysis: C, 64.34; H, 4.76; N, 30.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TU-2218; TU2218; TU 2218
IUPAC/Chemical Name
6-(6-(6-methylpyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridine
InChi Key
YPVPNCPOMKIVAJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H15N7/c1-11-3-2-4-13(21-11)15-16(23-8-7-18-17(23)22-15)12-5-6-14-19-10-20-24(14)9-12/h2-6,9-10H,7-8H2,1H3,(H,18,22)
SMILES Code
CC1=CC=CC(C(N=C2N3CCN2)=C3C4=CN5C(C=C4)=NC=N5)=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Kim NH, Lee J, Kim SH, Kang SH, Bae S, Yu CH, Seo J, Kim HT. ALK5/VEGFR2 dual inhibitor TU2218 alone or in combination with immune checkpoint inhibitors enhances immune-mediated antitumor effects. Cancer Immunol Immunother. 2024 Aug 6;73(10):190. doi: 10.1007/s00262-024-03777-4. PMID: 39105882; PMCID: PMC11303640.