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MedKoo Cat#: 128634 | Name: TAF-3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAF-3 is a Photosensitizer. TAF-3 showed excellent photostability has an ultrahigh type I ROS production efficiency (4.79 times that of methylene blue) and a photothermal conversion efficiency of 41.7%. TAF-3 improves the conjugation degree; produces an appropriate intramolecular charge transfer effect, which enhances its optical properties and phototherapeutic efficiency; and promotes a stronger immune cell death effect, reducing postoperative melanoma recurrence by 60%.

Chemical Structure

TAF-3
TAF-3
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128634

Name: TAF-3

CAS#: N/A

Chemical Formula: C61H41N3O

Exact Mass: 831.3250

Molecular Weight: 832.02

Elemental Analysis: C, 88.06; H, 4.97; N, 5.05; O, 1.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TAF-3; TAF3; TAF 3
IUPAC/Chemical Name
2-(3-(4-((4'-methoxy-[1,1'-biphenyl]-4-yl)(4-(1,2,2-triphenylvinyl)phenyl)amino)phenyl)-9H-fluoren-9-ylidene)malononitrile
InChi Key
UWXIRVDKWLGOOE-UHFFFAOYSA-N
InChi Code
InChI=1S/C61H41N3O/c1-65-54-36-27-43(28-37-54)42-21-30-51(31-22-42)64(52-32-23-44(24-33-52)49-29-38-57-58(39-49)55-19-11-12-20-56(55)61(57)50(40-62)41-63)53-34-25-48(26-35-53)60(47-17-9-4-10-18-47)59(45-13-5-2-6-14-45)46-15-7-3-8-16-46/h2-39H,1H3
SMILES Code
COC1=CC=C(C=C1)C2=CC=C(C=C2)N(C3=CC=C(C=C3)C4=CC=C5C(C6=C(/C5=C(C#N)\C#N)C=CC=C6)=C4)C7=CC=C(/C(C8=CC=CC=C8)=C(C9=CC=CC=C9)/C%10=CC=CC=C%10)C=C7
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 832.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Wang Q, Yang L, Xing X, Liang W, Wu R, Xiong C, Wu M, Zhong C, Zhang H, Wang S, Xia F, Lou X, Chen D, Dai J. Regio-isomerization Optimization Strategy for Photosensitizers: Achieving Ultrahigh Type I Reactive Oxygen Species Generation to Enhance Cancer Photoimmunotherapy. J Med Chem. 2025 Mar 13. doi: 10.1021/acs.jmedchem.4c02916. Epub ahead of print. PMID: 40080540.