UNC9426 is a Potent and Orally Bioavailable TYRO3-Specific Inhibitor (IC50=2.1 nM). UNC9426 showed an excellent Ambit selectivity score (S50 (1.0 μM) = 0.026) and favorable pharmacokinetic properties in mice. Treatment with UNC9426 reduced platelet aggregation without increasing bleeding time and blocked TYRO3-dependent functions in tumor cells and macrophages, implicating its utility for multiple indications.
MedKoo Cat#: 128624
Name: UNC9426
CAS#: 3051784-94-9
Chemical Formula: C32H34F6N6O
Exact Mass: 632.2698
Molecular Weight: 632.66
Elemental Analysis: C, 60.75; H, 5.42; F, 18.02; N, 13.28; O, 2.53
The following data is based on the product molecular weight 632.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
