U-31355 | HIV-1 reverse transcriptase inhibitor

MedKoo Cat#: 128609 | Name: U-31355

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U-31355 is a potent inhibitor of HIV-1 reverse transcriptase. U-31355 possessed a significantly higher binding affinity for the enzyme-substrate complexes, than for the free enzyme and consequently did not directly affect the functions of the substrate binding sites.

Chemical Structure

U-31355

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128609

Name: U-31355

CAS#: N/A

Chemical Formula: C11H10ClN3S

Exact Mass: 251.0284

Molecular Weight: 251.73

Elemental Analysis: C, 52.48; H, 4.00; Cl, 14.08; N, 16.69; S, 12.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

U-31355; U 31355; U31355

IUPAC/Chemical Name

2-(benzylthio)-6-chloropyrimidin-4-amine

InChi Key

LGTXUPUULSWTNA-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H10ClN3S/c12-9-6-10(13)15-11(14-9)16-7-8-4-2-1-3-5-8/h1-6H,7H2,(H2,13,14,15)

SMILES Code

ClC1=NC(SCC2=CC=CC=C2)=NC(N)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 251.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Althaus IW, Chou KC, Lemay RJ, Franks KM, Deibel MR, Kezdy FJ, Resnick L, Busso ME, So AG, Downey KM, Romero DL, Thomas RC, Aristoff PA, Tarpley WG, Reusser F. The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase. Biochem Pharmacol. 1996 Mar 22;51(6):743-50. doi: 10.1016/0006-2952(95)02390-9. PMID: 8602869.