MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 128604 | Name: MS41
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively.

Chemical Structure

MS41
MS41
CAS#2768610-97-3

Theoretical Analysis

MedKoo Cat#: 128604

Name: MS41

CAS#: 2768610-97-3

Chemical Formula: C56H70N8O9S

Exact Mass: 1030.4986

Molecular Weight: 1031.28

Elemental Analysis: C, 65.22; H, 6.84; N, 10.87; O, 13.96; S, 3.11

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
MS41; MS-41; MS 41
IUPAC/Chemical Name
5-(4-(dimethylcarbamoyl)-3-hydroxyphenyl)-N-((R)-6-((10-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-10-oxodecyl)carbamoyl)-2,3-dihydro-1H-inden-1-yl)isoxazole-3-carboxamide
InChi Key
XPICNVKPGAOVBF-VCNVHFLLSA-N
InChi Code
InChI=1S/C56H70N8O9S/c1-33(35-16-19-37(20-17-35)49-34(2)58-32-74-49)59-53(70)45-29-40(65)31-64(45)55(72)50(56(3,4)5)61-48(67)15-13-11-9-8-10-12-14-26-57-51(68)39-21-18-36-23-25-43(42(36)27-39)60-52(69)44-30-47(73-62-44)38-22-24-41(46(66)28-38)54(71)63(6)7/h16-22,24,27-28,30,32-33,40,43,45,50,65-66H,8-15,23,25-26,29,31H2,1-7H3,(H,57,68)(H,59,70)(H,60,69)(H,61,67)/t33-,40+,43+,45-,50+/m0/s1
SMILES Code
CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCNC(C4=CC=C5CC[C@H](C5=C4)NC(C6=NOC(C7=CC(O)=C(C=C7)C(N(C)C)=O)=C6)=O)=O)=O)=O)O)=O)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,031.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Xue Z, Qin L, Xuan H, Luo K, Huang M, Xie L, Su Y, Xu L, Harsh J, Dale B, Shi X, Chen X, Kaniskan HÜ, Jin J, Wen H. A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Sci Adv. 2024 Aug 30;10(35):eado1432. doi: 10.1126/sciadv.ado1432. Epub 2024 Aug 28. PMID: 39196923; PMCID: PMC11352836.