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MedKoo Cat#: 146051 | Name: Rhodiosin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rhodiosin is a bioactive compound derived from the Rhodiola genus, particularly Rhodiola rosea, a plant known for its adaptogenic properties. It is believed to contribute to the plant's ability to enhance physical and mental endurance, reduce fatigue, and combat stress. Rhodiosin works by modulating the activity of certain neurotransmitters, such as serotonin and dopamine, and by influencing stress response pathways, including the regulation of cortisol levels. This makes rhodiosin useful in promoting cognitive function, improving mood, and supporting overall vitality, often used in supplements for stress relief and energy enhancement.

Chemical Structure

Rhodiosin
Rhodiosin
CAS#86831-54-1

Theoretical Analysis

MedKoo Cat#: 146051

Name: Rhodiosin

CAS#: 86831-54-1

Chemical Formula: C27H30O16

Exact Mass: 610.1500

Molecular Weight: 610.52

Elemental Analysis: C, 53.12; H, 4.95; O, 41.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Rhodiosin;
IUPAC/Chemical Name
7-(((2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,5,8-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChi Key
WXBBQBYCUTXTJQ-ULMXTSOFSA-N
InChi Code
1S/C27H30O16/c1-8-15(31)25(43-26-21(37)19(35)16(32)13(7-28)41-26)22(38)27(39-8)40-12-6-11(30)14-18(34)20(36)23(42-24(14)17(12)33)9-2-4-10(29)5-3-9/h2-6,8,13,15-16,19,21-22,25-33,35-38H,7H2,1H3/t8-,13+,15-,16+,19-,21+,22+,25+,26-,27-/m0/s1
SMILES Code
C[C@@H]1O[C@@H](OC2=CC(O)=C3C(=O)C(O)=C(OC3=C2O)C4=CC=C(O)C=C4)[C@H](O)[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 610.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Péter Zomborszki Z, Kúsz N, Csupor D, Peschel W. Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control? Pharm Biol. 2019 Dec;57(1):295-305. doi: 10.1080/13880209.2019.1577460. PMID: 31356124; PMCID: PMC6711108. 2: Wang L, Wu L, Li J, Cailang B, Zhao X, Yue H. Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of α‑glucosidase. Phytomedicine. 2024 Sep;132:155836. doi: 10.1016/j.phymed.2024.155836. Epub 2024 Jun 22. PMID: 38941814. 3: Zhu M, Qu J, Deng Q. Identification of potential inhibitors against Staphylococcus aureus shikimate dehydrogenase through virtual screening and susceptibility test. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2301768. doi: 10.1080/14756366.2024.2301768. Epub 2024 Jan 17. PMID: 38234148; PMCID: PMC10798293. 4: Döring K, Langeder J, Duwe S, Tahir A, Grienke U, Rollinger JM, Schmidtke M. Insights into the direct anti-influenza virus mode of action of Rhodiola rosea. Phytomedicine. 2022 Feb;96:153895. doi: 10.1016/j.phymed.2021.153895. Epub 2021 Dec 14. PMID: 35026524. 5: Xu W, Zhang T, Wang Z, Liu T, Liu Y, Cao Z, Sui Z. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea. Pharmazie. 2013 Dec;68(12):974-6. PMID: 24400445. 6: Langeder J, Grienke U, Döring K, Jafari M, Ehrhardt C, Schmidtke M, Rollinger JM. High-performance Countercurrent Chromatography to Access Rhodiola rosea Influenza Virus Inhibiting Constituents. Planta Med. 2021 Aug;87(10-11):818-826. doi: 10.1055/a-1228-8473. Epub 2020 Aug 11. PMID: 32781473. 7: Yan X, Liu J, Zhu M, Liu L, Chen Y, Zhang Y, Feng M, Jia Z, Xiao H. Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness. Pharm Biol. 2021 Dec;59(1):1540-1550. doi: 10.1080/13880209.2021.1992449. PMID: 34739769; PMCID: PMC8594887. 8: Zakharenko AM, Razgonova MP, Pikula KS, Golokhvast KS. Simultaneous Determination of 78 Compounds of Rhodiola rosea Extract by Supercritical CO2-Extraction and HPLC-ESI-MS/MS Spectrometry. Biochem Res Int. 2021 Jul 6;2021:9957490. doi: 10.1155/2021/9957490. PMID: 34306755; PMCID: PMC8279876. 9: Kobayashi K, Yamada K, Murata T, Hasegawa T, Takano F, Koga K, Fushiya S, Batkhuu J, Yoshizaki F. Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal. Planta Med. 2008 Nov;74(14):1716-9. doi: 10.1055/s-0028-1088318. Epub 2008 Nov 3. PMID: 18982538. 10: Slimestad R, Johny A, Thomsen MG, Karlsen CR, Rosnes JT. Chemical Profiling and Biological Activity of Extracts from Nine Norwegian Medicinal and Aromatic Plants. Molecules. 2022 Oct 28;27(21):7335. doi: 10.3390/molecules27217335. PMID: 36364156; PMCID: PMC9656764. 11: Erst AA, Petruk AA, Zibareva LN, Erst AS. Morphological, Histochemical and Biochemical Features of Cultivated Rhodiola rosea (Altai Mountains Ecotype). Contemp Probl Ecol. 2021;14(6):701-710. doi: 10.1134/S1995425521060135. Epub 2021 Dec 20. PMID: 34956551; PMCID: PMC8685791. 12: Zhang X, Zhu J, Yan J, Xiao Y, Yang R, Huang R, Zhou J, Wang Z, Xiao W, Zheng C, Wang Y. Systems pharmacology unravels the synergic target space and therapeutic potential of Rhodiola rosea L. for non-small cell lung cancer. Phytomedicine. 2020 Dec;79:153326. doi: 10.1016/j.phymed.2020.153326. Epub 2020 Sep 1. PMID: 32992083. 13: Feng ZY, Ma YX, Wang H, Chen M. [Studies on chemical constituents of stems of Herpetospermum pedunculosum]. Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(11):2571-2577. Chinese. doi: 10.19540/j.cnki.cjcmm.20200227.201. PMID: 32627491. 14: Fan W, Tezuka Y, Ni KM, Kadota S. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401. doi: 10.1248/cpb.49.396. PMID: 11310664. 15: Choe KI, Kwon JH, Park KH, Oh MH, Kim MH, Kim HH, Cho SH, Chung EK, Ha SY, Lee MW. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR. Molecules. 2012 Sep 27;17(10):11484-94. doi: 10.3390/molecules171011484. PMID: 23018923; PMCID: PMC6268498. 16: Liu GD, Zhao YW, Li YJ, Wang XJ, Si HH, Huang WZ, Wang ZZ, Ma SP, Xiao W. Qualitative and quantitative analysis of major constituents from Dazhu Hongjingtian capsule by UPLC/Q-TOF-MS/MS combined with UPLC/QQQ-MS/MS. Biomed Chromatogr. 2017 Jun;31(6). doi: 10.1002/bmc.3887. Epub 2017 Jan 16. PMID: 27862112. 17: Li FJ, Liu Y, Yuan Y, Yang B, Liu ZM, Huang LQ. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532. doi: 10.1016/j.ijbiomac.2017.06.066. Epub 2017 Jun 16. PMID: 28625836. 18: Ma S, Hu L, Ma C, Lv W, Wang H. Application and recovery of ionic liquids in the preparative separation of four flavonoids from Rhodiola rosea by on-line three-dimensional liquid chromatography. J Sep Sci. 2014 Sep;37(17):2314-21. doi: 10.1002/jssc.201400305. Epub 2014 Jul 10. PMID: 24916654. 19: Liang ZL, Zhang XY, Wang F, Zhang K, Liu HF, Liu HL. Understanding molecular mechanisms of Rhodiola rosea for the treatment of acute mountain sickness through computational approaches (a STROBE-compliant article). Medicine (Baltimore). 2018 Sep;97(39):e11886. doi: 10.1097/MD.0000000000011886. PMID: 30278484; PMCID: PMC6181534. 20: Nakamura S, Li X, Matsuda H, Ninomiya K, Morikawa T, Yamaguti K, Yoshikawa M. Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1505-11. doi: 10.1248/cpb.55.1505. PMID: 17917296.

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